Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review
Background: Salivary gland dysfunction is caused by various pathological conditions including radiation therapy. Regeneration of the salivary gland components will pave a new path in restoring its function. Aim: This systematic review aims to illustrate the various bio-materials used as a scaffold i...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024001845 |
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| author | M. Harinisubasri Divya Bose Dineshkumar Thayalan Rajkumar Krishnan Rameshkumar Annasamy |
| author_facet | M. Harinisubasri Divya Bose Dineshkumar Thayalan Rajkumar Krishnan Rameshkumar Annasamy |
| author_sort | M. Harinisubasri |
| collection | DOAJ |
| description | Background: Salivary gland dysfunction is caused by various pathological conditions including radiation therapy. Regeneration of the salivary gland components will pave a new path in restoring its function. Aim: This systematic review aims to illustrate the various bio-materials used as a scaffold in the 3-dimensional regeneration of the salivary gland. Materials and methods: Electronic databases like PubMed, Scopus, and Web of Science were used as search engines to search for articles related to various biomaterials used in the three-dimensional regeneration of salivary glands. Only original, full-length articles published in the English language were included for the review. Results: Totally 17 articles were chosen among which 15 articles were based on in vitro studies and the remaining 2 were based on in vivo studies. Biomaterials like hyaluronic acid-based, fibrin, Polyethylene glycol, Decellularized extracellular matrix hydro-gels, egg white-based scaffolds, and silk fibroin scaffolds have been tried. In 52.9% of the studies, Acinar components were formed along with the duct formation in 52.9% of the studies followed by the formation of the myoepithelial component in 29.4% of the studies with neuronal innervation only in 5.88% of the studies. Conclusion: Hyaluronic acid-based hydrogel scaffold proved to be a promising biomaterial that produced functional salivary glands in in-vitro conditions. However, more detailed studies under in-vivo conditions in the animal model could pave a new path for regularly using these bio-materials for regeneration methods. |
| format | Article |
| id | doaj-art-e5703f5b78c64b089459d26588061970 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-e5703f5b78c64b089459d265880619702025-01-09T06:15:52ZengElsevierOral Oncology Reports2772-90602024-06-0110100338Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic reviewM. Harinisubasri0Divya Bose1Dineshkumar Thayalan2Rajkumar Krishnan3Rameshkumar Annasamy4Department of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaCorresponding author.; Department of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaBackground: Salivary gland dysfunction is caused by various pathological conditions including radiation therapy. Regeneration of the salivary gland components will pave a new path in restoring its function. Aim: This systematic review aims to illustrate the various bio-materials used as a scaffold in the 3-dimensional regeneration of the salivary gland. Materials and methods: Electronic databases like PubMed, Scopus, and Web of Science were used as search engines to search for articles related to various biomaterials used in the three-dimensional regeneration of salivary glands. Only original, full-length articles published in the English language were included for the review. Results: Totally 17 articles were chosen among which 15 articles were based on in vitro studies and the remaining 2 were based on in vivo studies. Biomaterials like hyaluronic acid-based, fibrin, Polyethylene glycol, Decellularized extracellular matrix hydro-gels, egg white-based scaffolds, and silk fibroin scaffolds have been tried. In 52.9% of the studies, Acinar components were formed along with the duct formation in 52.9% of the studies followed by the formation of the myoepithelial component in 29.4% of the studies with neuronal innervation only in 5.88% of the studies. Conclusion: Hyaluronic acid-based hydrogel scaffold proved to be a promising biomaterial that produced functional salivary glands in in-vitro conditions. However, more detailed studies under in-vivo conditions in the animal model could pave a new path for regularly using these bio-materials for regeneration methods.http://www.sciencedirect.com/science/article/pii/S2772906024001845Salivary glandBio-materialsScaffoldHydrogelsDysfunctionTreatment |
| spellingShingle | M. Harinisubasri Divya Bose Dineshkumar Thayalan Rajkumar Krishnan Rameshkumar Annasamy Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review Oral Oncology Reports Salivary gland Bio-materials Scaffold Hydrogels Dysfunction Treatment |
| title | Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review |
| title_full | Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review |
| title_fullStr | Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review |
| title_full_unstemmed | Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review |
| title_short | Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review |
| title_sort | biomaterials used in regeneration of salivary gland in three dimensional culture system a systematic review |
| topic | Salivary gland Bio-materials Scaffold Hydrogels Dysfunction Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024001845 |
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