Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications
Stimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. These hydrogels are designed to respond to specific stimuli, such as pH, temperature, light, and enzyme a...
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MDPI AG
2025-05-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/11/6/420 |
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| author | Ke Ding Mingrui Liao Yingyu Wang Jian R. Lu |
| author_facet | Ke Ding Mingrui Liao Yingyu Wang Jian R. Lu |
| author_sort | Ke Ding |
| collection | DOAJ |
| description | Stimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. These hydrogels are designed to respond to specific stimuli, such as pH, temperature, light, and enzyme activity, enabling precise regulation of drug release, antimicrobial activity, and tissue regeneration. Composite stimuli-responsive hydrogels, by integrating multiple response mechanisms and functions, show potential for addressing the diverse needs of wound healing. This review explores the biological mechanisms of wound healing, the design and classification of composite stimuli-responsive hydrogels, and the key fabrication strategies employed to optimise their properties. Despite their immense potential, unresolved challenges such as biocompatibility, long-term stability, and scalability continue to limit their translation into clinical practice. Future research will focus on integrating hydrogels with smart wearable devices, AI-driven personalised medicine, and 3D bioprinting technologies to develop next-generation wound care solutions. With continuous advancements in biomaterials science and bioengineering, stimuli-responsive hydrogels hold great promise for revolutionising wound management. |
| format | Article |
| id | doaj-art-e56ab32273ba4c28b2c9b52cda0bfc93 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-e56ab32273ba4c28b2c9b52cda0bfc932025-08-20T03:27:25ZengMDPI AGGels2310-28612025-05-0111642010.3390/gels11060420Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and ApplicationsKe Ding0Mingrui Liao1Yingyu Wang2Jian R. Lu3Biological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UKBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UKBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UKBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UKStimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. These hydrogels are designed to respond to specific stimuli, such as pH, temperature, light, and enzyme activity, enabling precise regulation of drug release, antimicrobial activity, and tissue regeneration. Composite stimuli-responsive hydrogels, by integrating multiple response mechanisms and functions, show potential for addressing the diverse needs of wound healing. This review explores the biological mechanisms of wound healing, the design and classification of composite stimuli-responsive hydrogels, and the key fabrication strategies employed to optimise their properties. Despite their immense potential, unresolved challenges such as biocompatibility, long-term stability, and scalability continue to limit their translation into clinical practice. Future research will focus on integrating hydrogels with smart wearable devices, AI-driven personalised medicine, and 3D bioprinting technologies to develop next-generation wound care solutions. With continuous advancements in biomaterials science and bioengineering, stimuli-responsive hydrogels hold great promise for revolutionising wound management.https://www.mdpi.com/2310-2861/11/6/420stimuli-responsive hydrogelscomposite hydrogelswound healingbioactive agentscontrolled drug releaseantibacterial hydrogels |
| spellingShingle | Ke Ding Mingrui Liao Yingyu Wang Jian R. Lu Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications Gels stimuli-responsive hydrogels composite hydrogels wound healing bioactive agents controlled drug release antibacterial hydrogels |
| title | Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications |
| title_full | Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications |
| title_fullStr | Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications |
| title_full_unstemmed | Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications |
| title_short | Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications |
| title_sort | advances in composite stimuli responsive hydrogels for wound healing mechanisms and applications |
| topic | stimuli-responsive hydrogels composite hydrogels wound healing bioactive agents controlled drug release antibacterial hydrogels |
| url | https://www.mdpi.com/2310-2861/11/6/420 |
| work_keys_str_mv | AT keding advancesincompositestimuliresponsivehydrogelsforwoundhealingmechanismsandapplications AT mingruiliao advancesincompositestimuliresponsivehydrogelsforwoundhealingmechanismsandapplications AT yingyuwang advancesincompositestimuliresponsivehydrogelsforwoundhealingmechanismsandapplications AT jianrlu advancesincompositestimuliresponsivehydrogelsforwoundhealingmechanismsandapplications |