Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System
Background. Histoplasmosis is a common fungal infection in the southeastern, mid-Atlantic, and central states; however, its presentation can be atypical. Case Presentation. We report a case of Histoplasma capsulatum infection presenting as slowly progressive weakness in the lower extremities, follow...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/581415 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166920371765248 |
|---|---|
| author | Albert J. Eid John D. Leever Kathrin Husmann |
| author_facet | Albert J. Eid John D. Leever Kathrin Husmann |
| author_sort | Albert J. Eid |
| collection | DOAJ |
| description | Background. Histoplasmosis is a common fungal infection in the southeastern, mid-Atlantic, and central states; however, its presentation can be atypical. Case Presentation. We report a case of Histoplasma capsulatum infection presenting as slowly progressive weakness in the lower extremities, followed by the development of numbness below the midthoracic area, urinary incontinence, and slurred speech. Brain MRI showed leptomeningeal enhancement, predominantly linear, involving the basal cisterns, the brainstem, and spinal cord. Cerebrospinal fluid analysis showed lymphocytic pleocytosis. Discussion. CNS histoplasmosis is usually seen in patients with disseminated histoplasmosis. Isolated CNS histoplasmosis is rarely seen, especially in immunocompetent patients. Conclusions. Histoplasmosis should be considered in the differential diagnosis of patients experiencing slowly progressive neurological deficit. |
| format | Article |
| id | doaj-art-e56a73b722404bf28a32d76a059dfbb8 |
| institution | OA Journals |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-e56a73b722404bf28a32d76a059dfbb82025-08-20T02:21:19ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/581415581415Compartmentalized Histoplasma capsulatum Infection of the Central Nervous SystemAlbert J. Eid0John D. Leever1Kathrin Husmann2Division of Infectious Diseases, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADepartment of Radiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADepartment of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USABackground. Histoplasmosis is a common fungal infection in the southeastern, mid-Atlantic, and central states; however, its presentation can be atypical. Case Presentation. We report a case of Histoplasma capsulatum infection presenting as slowly progressive weakness in the lower extremities, followed by the development of numbness below the midthoracic area, urinary incontinence, and slurred speech. Brain MRI showed leptomeningeal enhancement, predominantly linear, involving the basal cisterns, the brainstem, and spinal cord. Cerebrospinal fluid analysis showed lymphocytic pleocytosis. Discussion. CNS histoplasmosis is usually seen in patients with disseminated histoplasmosis. Isolated CNS histoplasmosis is rarely seen, especially in immunocompetent patients. Conclusions. Histoplasmosis should be considered in the differential diagnosis of patients experiencing slowly progressive neurological deficit.http://dx.doi.org/10.1155/2015/581415 |
| spellingShingle | Albert J. Eid John D. Leever Kathrin Husmann Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System Case Reports in Infectious Diseases |
| title | Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System |
| title_full | Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System |
| title_fullStr | Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System |
| title_full_unstemmed | Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System |
| title_short | Compartmentalized Histoplasma capsulatum Infection of the Central Nervous System |
| title_sort | compartmentalized histoplasma capsulatum infection of the central nervous system |
| url | http://dx.doi.org/10.1155/2015/581415 |
| work_keys_str_mv | AT albertjeid compartmentalizedhistoplasmacapsulatuminfectionofthecentralnervoussystem AT johndleever compartmentalizedhistoplasmacapsulatuminfectionofthecentralnervoussystem AT kathrinhusmann compartmentalizedhistoplasmacapsulatuminfectionofthecentralnervoussystem |