Reactivation, Replay, and Preplay: How It Might All Fit Together
Sequential activation of neurons that occurs during “offline” states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-called reactivation, or replay, has been observed in a number of different brain regions such as the striatum,...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/203462 |
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| author | Laure Buhry Amir H. Azizi Sen Cheng |
| author_facet | Laure Buhry Amir H. Azizi Sen Cheng |
| author_sort | Laure Buhry |
| collection | DOAJ |
| description | Sequential activation of neurons that occurs during “offline” states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-called reactivation, or replay, has been observed in a number of different brain regions such as the striatum, prefrontal cortex, primary visual cortex and, most prominently, the hippocampus. Reactivation largely co-occurs together with hippocampal sharp-waves/ripples, brief high-frequency bursts in the local field potential. Here, we first review the mounting evidence for the hypothesis that reactivation is the neural mechanism for memory consolidation during sleep. We then discuss recent results that suggest that offline sequential activity in the waking state might not be simple repetitions of previously experienced sequences. Some offline sequential activity occurs before animals are exposed to a novel environment for the first time, and some sequences activated offline correspond to trajectories never experienced by the animal. We propose a conceptual framework for the dynamics of offline sequential activity that can parsimoniously describe a broad spectrum of experimental results. These results point to a potentially broader role of offline sequential activity in cognitive functions such as maintenance of spatial representation, learning, or planning. |
| format | Article |
| id | doaj-art-e56698715bfe4a6f89b105caf4688073 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e56698715bfe4a6f89b105caf46880732025-08-20T03:26:17ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/203462203462Reactivation, Replay, and Preplay: How It Might All Fit TogetherLaure Buhry0Amir H. Azizi1Sen Cheng2Mercator Research Group “Structure of Memory”, Ruhr-University Bochum, Universitaetsstraße 150, 44801 Bochum, GermanyMercator Research Group “Structure of Memory”, Ruhr-University Bochum, Universitaetsstraße 150, 44801 Bochum, GermanyMercator Research Group “Structure of Memory”, Ruhr-University Bochum, Universitaetsstraße 150, 44801 Bochum, GermanySequential activation of neurons that occurs during “offline” states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-called reactivation, or replay, has been observed in a number of different brain regions such as the striatum, prefrontal cortex, primary visual cortex and, most prominently, the hippocampus. Reactivation largely co-occurs together with hippocampal sharp-waves/ripples, brief high-frequency bursts in the local field potential. Here, we first review the mounting evidence for the hypothesis that reactivation is the neural mechanism for memory consolidation during sleep. We then discuss recent results that suggest that offline sequential activity in the waking state might not be simple repetitions of previously experienced sequences. Some offline sequential activity occurs before animals are exposed to a novel environment for the first time, and some sequences activated offline correspond to trajectories never experienced by the animal. We propose a conceptual framework for the dynamics of offline sequential activity that can parsimoniously describe a broad spectrum of experimental results. These results point to a potentially broader role of offline sequential activity in cognitive functions such as maintenance of spatial representation, learning, or planning.http://dx.doi.org/10.1155/2011/203462 |
| spellingShingle | Laure Buhry Amir H. Azizi Sen Cheng Reactivation, Replay, and Preplay: How It Might All Fit Together Neural Plasticity |
| title | Reactivation, Replay, and Preplay: How It Might All Fit Together |
| title_full | Reactivation, Replay, and Preplay: How It Might All Fit Together |
| title_fullStr | Reactivation, Replay, and Preplay: How It Might All Fit Together |
| title_full_unstemmed | Reactivation, Replay, and Preplay: How It Might All Fit Together |
| title_short | Reactivation, Replay, and Preplay: How It Might All Fit Together |
| title_sort | reactivation replay and preplay how it might all fit together |
| url | http://dx.doi.org/10.1155/2011/203462 |
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