Small Dumbbell Oligonucleotides Inhibitors of RNase H Activity of MOMULV Reverse Transcriptase

Small Dumbbell Oligonucleotides Inhibitors of RNase H Activity of MOMULV Reverse Transcriptase

The small dumbbell oligonucleotides containing loops of phosphodiester (OL-1), two trimethylene, C3 moieties in each loop (OL-2) and phosphorothioate (OL-3) linkages were synthesized. Incubation of OL-1 and OL-2 with S-1 nuclease generated break down products whereas incubation of OL-3 did not resul...

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Bibliographic Details
Main Author:	Ajay Kumar
Format:	Article
Language:	English
Published:	Wiley 2011-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2011/584368
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