Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders
GABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development, also recent stu...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/734231 |
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| author | Bidisha Chattopadhyaya |
| author_facet | Bidisha Chattopadhyaya |
| author_sort | Bidisha Chattopadhyaya |
| collection | DOAJ |
| description | GABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development, also recent studies involve a number of molecular players involved in the process. Emphasizing the molecular mechanisms of GABAergic synapse formation, in particular basket cell perisomatic synapses, this paper draws attention to the links between critical period plasticity, GABAergic synapse maturation, and the consequences of its dysfunction on the development of the nervous system. |
| format | Article |
| id | doaj-art-e56165265dd4467b86ed24a269123c6f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e56165265dd4467b86ed24a269123c6f2025-02-03T06:13:58ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/734231734231Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental DisordersBidisha Chattopadhyaya0Centre de Recherche, CHU Ste-Justine, Université de Montréal, 3175, Chemin de la Côte-Ste-Catherine, Montréal, QC, H3T 1C5, CanadaGABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development, also recent studies involve a number of molecular players involved in the process. Emphasizing the molecular mechanisms of GABAergic synapse formation, in particular basket cell perisomatic synapses, this paper draws attention to the links between critical period plasticity, GABAergic synapse maturation, and the consequences of its dysfunction on the development of the nervous system.http://dx.doi.org/10.1155/2011/734231 |
| spellingShingle | Bidisha Chattopadhyaya Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders Neural Plasticity |
| title | Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders |
| title_full | Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders |
| title_fullStr | Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders |
| title_full_unstemmed | Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders |
| title_short | Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders |
| title_sort | molecular mechanisms underlying activity dependent gabaergic synapse development and plasticity and its implications for neurodevelopmental disorders |
| url | http://dx.doi.org/10.1155/2011/734231 |
| work_keys_str_mv | AT bidishachattopadhyaya molecularmechanismsunderlyingactivitydependentgabaergicsynapsedevelopmentandplasticityanditsimplicationsforneurodevelopmentaldisorders |