Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

ABSTRACT Cancer cells are characterized by the Warburg effect, which hijacks glycolysis and hinders OXPHOS. Pyruvate dehydrogenase kinase 1 (PDK1) is a key modulator in the Warburg effect and is highly expressed in tumor cells. We utilize PROTAC technology to design compounds that could achieve long...

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Bibliographic Details
Main Authors: Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Exploration
Subjects:
immunogenic cell death
PROTAC
pyruvate dehydrogenase kinase
Warburg effect
Online Access:https://doi.org/10.1002/EXP.20240031
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