Neurotrauma and Inflammation: CNS and PNS Responses
Traumatic injury to the central nervous system (CNS) or the peripheral nervous system (PNS) triggers a cascade of events which culminate in a robust inflammatory reaction. The role played by inflammation in the course of degeneration and regeneration is not completely elucidated. While, in periphera...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/251204 |
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| _version_ | 1849435360204947456 |
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| author | Bruno Siqueira Mietto Klauss Mostacada Ana Maria Blanco Martinez |
| author_facet | Bruno Siqueira Mietto Klauss Mostacada Ana Maria Blanco Martinez |
| author_sort | Bruno Siqueira Mietto |
| collection | DOAJ |
| description | Traumatic injury to the central nervous system (CNS) or the peripheral nervous system (PNS) triggers a cascade of events which culminate in a robust inflammatory reaction. The role played by inflammation in the course of degeneration and regeneration is not completely elucidated. While, in peripheral nerves, the inflammatory response is assumed to be essential for normal progression of Wallerian degeneration and regeneration, CNS trauma inflammation is often associated with poor recovery. In this review, we discuss key mechanisms that trigger the inflammatory reaction after nervous system trauma, emphasizing how inflammations in both CNS and PNS differ from each other, in terms of magnitude, cell types involved, and effector molecules. Knowledge of the precise mechanisms that elicit and maintain inflammation after CNS and PNS tissue trauma and their effect on axon degeneration and regeneration is crucial for the identification of possible pharmacological drugs that can positively affect the tissue regenerative capacity. |
| format | Article |
| id | doaj-art-e55e8a6f65514cdfa753dd2fed520b06 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e55e8a6f65514cdfa753dd2fed520b062025-08-20T03:26:20ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/251204251204Neurotrauma and Inflammation: CNS and PNS ResponsesBruno Siqueira Mietto0Klauss Mostacada1Ana Maria Blanco Martinez2Laboratório de Neurodegeneração e Reparo, Departamento de Patologia, Faculdade de Medicina, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-550 Rio de Janeiro, RJ, BrazilLaboratório de Neurodegeneração e Reparo, Departamento de Patologia, Faculdade de Medicina, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-550 Rio de Janeiro, RJ, BrazilLaboratório de Neurodegeneração e Reparo, Departamento de Patologia, Faculdade de Medicina, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-550 Rio de Janeiro, RJ, BrazilTraumatic injury to the central nervous system (CNS) or the peripheral nervous system (PNS) triggers a cascade of events which culminate in a robust inflammatory reaction. The role played by inflammation in the course of degeneration and regeneration is not completely elucidated. While, in peripheral nerves, the inflammatory response is assumed to be essential for normal progression of Wallerian degeneration and regeneration, CNS trauma inflammation is often associated with poor recovery. In this review, we discuss key mechanisms that trigger the inflammatory reaction after nervous system trauma, emphasizing how inflammations in both CNS and PNS differ from each other, in terms of magnitude, cell types involved, and effector molecules. Knowledge of the precise mechanisms that elicit and maintain inflammation after CNS and PNS tissue trauma and their effect on axon degeneration and regeneration is crucial for the identification of possible pharmacological drugs that can positively affect the tissue regenerative capacity.http://dx.doi.org/10.1155/2015/251204 |
| spellingShingle | Bruno Siqueira Mietto Klauss Mostacada Ana Maria Blanco Martinez Neurotrauma and Inflammation: CNS and PNS Responses Mediators of Inflammation |
| title | Neurotrauma and Inflammation: CNS and PNS Responses |
| title_full | Neurotrauma and Inflammation: CNS and PNS Responses |
| title_fullStr | Neurotrauma and Inflammation: CNS and PNS Responses |
| title_full_unstemmed | Neurotrauma and Inflammation: CNS and PNS Responses |
| title_short | Neurotrauma and Inflammation: CNS and PNS Responses |
| title_sort | neurotrauma and inflammation cns and pns responses |
| url | http://dx.doi.org/10.1155/2015/251204 |
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