Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico
Introduction: Type 2 diabetes mellitus (T2DM) is a growing condition that hinders the treatment and control of tuberculosis (TB). Several factors promote this comorbidity showing variations according to characteristics of the population affected. The objective was to identify the factors associated...
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The Journal of Infection in Developing Countries
2022-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15543 |
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| author | Zaira Liz Yague-Santiago María del Pilar Ramírez-Díaz Doireyner Daniel Velázquez- Ramírez Roberto Zenteno-Cuevas Jorge Fernando Luna-Hernández |
| author_facet | Zaira Liz Yague-Santiago María del Pilar Ramírez-Díaz Doireyner Daniel Velázquez- Ramírez Roberto Zenteno-Cuevas Jorge Fernando Luna-Hernández |
| author_sort | Zaira Liz Yague-Santiago |
| collection | DOAJ |
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Introduction: Type 2 diabetes mellitus (T2DM) is a growing condition that hinders the treatment and control of tuberculosis (TB). Several factors promote this comorbidity showing variations according to characteristics of the population affected. The objective was to identify the factors associated with the comorbidity of TB-T2DM in a rural population of Oaxaca, Mexico.
Methodology: This was an unpaired case-control study. Descriptive statistics was performed for clinical and sociodemographic variables. Logistic regression was used to calculate odds ratio (OR) to identify associated factors with TB-T2DM binomial.
Results: 126 controls (TB+ T2DM-) and 69 cases (TB+ T2DM+) were included. 43% were considered as indigenous population. Significant differences were found according to the groups. Treatment failure was higher in individuals with binomial (p = 0.015), as well as a higher bacillary load (two crosses) and presence of pulmonary TB (p ≤ 0.001). Association analysis showed that the risk factors of binomial were: female sex (OR = 2.47; 95% CI 1.24-4.92), age ≥ 45 years (OR = 2.90; 95% CI 1.42-5.92), body mass index ≥ 25 kg/m2 (OR = 2.69; 95% CI 1.25-5.77) and presenting > 6 symptoms (OR = 2.71; 95% CI 1.19-6.14).
Conclusions: This is the first report of this comorbidity in a rural Mexican population. The results highlight the growing problem of TB-T2DM, and the need to address the issue from an integral and gender perspective. Furthermore, mandatory screening is necessary in patients with T2DM to improve early diagnosis of TB and T2DM. This would promote better management of both conditions.
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| format | Article |
| id | doaj-art-e558ea1bf7df41a2ad759cdc303db7a3 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-e558ea1bf7df41a2ad759cdc303db7a32025-08-20T02:14:11ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-04-01160410.3855/jidc.15543Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, MexicoZaira Liz Yague-Santiago0María del Pilar Ramírez-Díaz1Doireyner Daniel Velázquez- Ramírez2Roberto Zenteno-Cuevas3Jorge Fernando Luna-Hernández4Unity of Biological and Health Sciences. University of the Isthmus, Campus Juchitan, Oaxaca, Mexico, Juchitán, Oaxaca, MéxicoUnity of Biological and Health Sciences. University of the Isthmus, Campus Juchitan, Oaxaca, Mexico, Juchitán, Oaxaca, MéxicoUnity of Biological and Health Sciences. University of the Isthmus, Campus Juchitan, Oaxaca, Mexico, Juchitán, Oaxaca, MéxicoPublic Health Institute, University of Veracruz, Xalapa, Veracruz, MexicoUnity of Biological and Health Sciences. University of the Isthmus, Campus Juchitan, Oaxaca, Mexico, Juchitán, Oaxaca, México Introduction: Type 2 diabetes mellitus (T2DM) is a growing condition that hinders the treatment and control of tuberculosis (TB). Several factors promote this comorbidity showing variations according to characteristics of the population affected. The objective was to identify the factors associated with the comorbidity of TB-T2DM in a rural population of Oaxaca, Mexico. Methodology: This was an unpaired case-control study. Descriptive statistics was performed for clinical and sociodemographic variables. Logistic regression was used to calculate odds ratio (OR) to identify associated factors with TB-T2DM binomial. Results: 126 controls (TB+ T2DM-) and 69 cases (TB+ T2DM+) were included. 43% were considered as indigenous population. Significant differences were found according to the groups. Treatment failure was higher in individuals with binomial (p = 0.015), as well as a higher bacillary load (two crosses) and presence of pulmonary TB (p ≤ 0.001). Association analysis showed that the risk factors of binomial were: female sex (OR = 2.47; 95% CI 1.24-4.92), age ≥ 45 years (OR = 2.90; 95% CI 1.42-5.92), body mass index ≥ 25 kg/m2 (OR = 2.69; 95% CI 1.25-5.77) and presenting > 6 symptoms (OR = 2.71; 95% CI 1.19-6.14). Conclusions: This is the first report of this comorbidity in a rural Mexican population. The results highlight the growing problem of TB-T2DM, and the need to address the issue from an integral and gender perspective. Furthermore, mandatory screening is necessary in patients with T2DM to improve early diagnosis of TB and T2DM. This would promote better management of both conditions. https://jidc.org/index.php/journal/article/view/15543Mycobacterium tuberculosiscomorbidityhyperglycemiarisk factors |
| spellingShingle | Zaira Liz Yague-Santiago María del Pilar Ramírez-Díaz Doireyner Daniel Velázquez- Ramírez Roberto Zenteno-Cuevas Jorge Fernando Luna-Hernández Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico Journal of Infection in Developing Countries Mycobacterium tuberculosis comorbidity hyperglycemia risk factors |
| title | Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico |
| title_full | Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico |
| title_fullStr | Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico |
| title_full_unstemmed | Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico |
| title_short | Factors associated with tuberculosis-diabetes mellitus type 2 binomial in rural population of Oaxaca, Mexico |
| title_sort | factors associated with tuberculosis diabetes mellitus type 2 binomial in rural population of oaxaca mexico |
| topic | Mycobacterium tuberculosis comorbidity hyperglycemia risk factors |
| url | https://jidc.org/index.php/journal/article/view/15543 |
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