Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study
Forceful corporal dilatation amidst penile prosthesis implantation may injure cavernosal arteries compromising penile vasculature. In this study, we aimed to compare the conventional and cavernosal sparing techniques regarding cavernosal artery preservation. Overall, 33 patients underwent inflatable...
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Wiley
2021-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2021/5548494 |
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| author | Adham Zaazaa Michaela Bayerle-Eder Ramzy Elnabarawy Mahmoud Elbitar Taymour Mostafa |
| author_facet | Adham Zaazaa Michaela Bayerle-Eder Ramzy Elnabarawy Mahmoud Elbitar Taymour Mostafa |
| author_sort | Adham Zaazaa |
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| description | Forceful corporal dilatation amidst penile prosthesis implantation may injure cavernosal arteries compromising penile vasculature. In this study, we aimed to compare the conventional and cavernosal sparing techniques regarding cavernosal artery preservation. Overall, 33 patients underwent inflatable penile prosthesis implantation with Coloplast Titan Touch® three-piece inflatable penile implants. 16 patients had conventional implantations with serial vigorous dilatations, while 17 patients were implanted with the cavernosal sparing technique, consisting of a single minimal corporal dilatation after an intraoperative intracavernosal injection (ICI) of Alprostadil. Postoperatively, a penile duplex Doppler ultrasound study was performed. Whenever a cavernosal artery was spared and thus successfully probed, its hemodynamics were studied before and after an oral administration of a phosphodiesterase type 5 inhibitor (PDE5i). A cavernosal artery was successfully probed in 16/17 (94%) of patients in the cavernosal sparing group compared to 5/16 (31%) of patients in the conventional group with a significant statistical difference (P=0.001). This demonstrated that the cavernosal sparing technique was superior to the conventional approach in preserving the cavernosal artery (odds ratio 35.2, 95% IC 3.5–344.2; P=0.0022). Whenever a cavernosal artery could be probed, its hemodynamic responsiveness was also preserved. This trial is registered with NCT03733860. |
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| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2021-01-01 |
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| series | Advances in Urology |
| spelling | doaj-art-e5551d60f9a84ff6b9043f13e3d3ffa02025-08-20T02:21:18ZengWileyAdvances in Urology1687-63691687-63772021-01-01202110.1155/2021/55484945548494Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) StudyAdham Zaazaa0Michaela Bayerle-Eder1Ramzy Elnabarawy2Mahmoud Elbitar3Taymour Mostafa4Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo 11562, EgyptDepartment of Endocrinology & Metabolism, Medical University of Vienna, Währinger Gürtel 18–20, Vienna 1090, AustriaDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo 11562, EgyptDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo 11562, EgyptDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo 11562, EgyptForceful corporal dilatation amidst penile prosthesis implantation may injure cavernosal arteries compromising penile vasculature. In this study, we aimed to compare the conventional and cavernosal sparing techniques regarding cavernosal artery preservation. Overall, 33 patients underwent inflatable penile prosthesis implantation with Coloplast Titan Touch® three-piece inflatable penile implants. 16 patients had conventional implantations with serial vigorous dilatations, while 17 patients were implanted with the cavernosal sparing technique, consisting of a single minimal corporal dilatation after an intraoperative intracavernosal injection (ICI) of Alprostadil. Postoperatively, a penile duplex Doppler ultrasound study was performed. Whenever a cavernosal artery was spared and thus successfully probed, its hemodynamics were studied before and after an oral administration of a phosphodiesterase type 5 inhibitor (PDE5i). A cavernosal artery was successfully probed in 16/17 (94%) of patients in the cavernosal sparing group compared to 5/16 (31%) of patients in the conventional group with a significant statistical difference (P=0.001). This demonstrated that the cavernosal sparing technique was superior to the conventional approach in preserving the cavernosal artery (odds ratio 35.2, 95% IC 3.5–344.2; P=0.0022). Whenever a cavernosal artery could be probed, its hemodynamic responsiveness was also preserved. This trial is registered with NCT03733860.http://dx.doi.org/10.1155/2021/5548494 |
| spellingShingle | Adham Zaazaa Michaela Bayerle-Eder Ramzy Elnabarawy Mahmoud Elbitar Taymour Mostafa Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study Advances in Urology |
| title | Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study |
| title_full | Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study |
| title_fullStr | Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study |
| title_full_unstemmed | Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study |
| title_short | Penile Hemodynamic Response to Phosphodiesterase Type V Inhibitors after Cavernosal Sparing Inflatable Penile Prosthesis Implantation: A Prospective Randomized Open-Blinded End-Point (PROBE) Study |
| title_sort | penile hemodynamic response to phosphodiesterase type v inhibitors after cavernosal sparing inflatable penile prosthesis implantation a prospective randomized open blinded end point probe study |
| url | http://dx.doi.org/10.1155/2021/5548494 |
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