Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients
<i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, <i>Acinetobacter</i> species, and <i>Candida</i> species are common ventilator-associated pneumonia (VAP) isolates. Whilst the clinical significance of <i>Candida</i> as a VAP isolate is unclear, ev...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/6/1181 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849431806582980608 |
|---|---|
| author | James Hurley |
| author_facet | James Hurley |
| author_sort | James Hurley |
| collection | DOAJ |
| description | <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, <i>Acinetobacter</i> species, and <i>Candida</i> species are common ventilator-associated pneumonia (VAP) isolates. Whilst the clinical significance of <i>Candida</i> as a VAP isolate is unclear, evidence is emerging that <i>Candida</i> interacts with bacteria, contributing to colonization susceptibility. Indirectly, VAP isolate data reflect patient colonization within cohorts. The objective here is to estimate the association between these three bacteria and Candida as VAP isolates. ICU cohorts were obtained by searching the literature for mechanically ventilated (MV) patient cohorts in which Candida was listed as an isolate among patients with VAP. Regression models of the associated VAP incidence per 100 MV patients, using random effects methods, incorporated group-level factors such as the year of publication, mode of VAP diagnosis, and ICU stay length. The median VAP incidence proportions for <i>Staphylococcus aureus, Pseudomonas aeruginosa,</i> and <i>Acinetobacter</i> species were 3.3 (IQR: 1.2–6.9), 3.6 (IQR: 1.8–5.7), and 1.2 (IQR: 0.4–4.1), respectively. Among 84 cohorts from 67 publications, <i>Staphylococcus aureus</i> (correlation coefficient = 0.759) and <i>Pseudomonas aeruginosa</i> (0.749), and less so <i>Acinetobacter</i> species (0.53)<i>,</i> each show correlation with the isolation of <i>Candida</i> species among these ICU populations. These associations may underlie the poor prognosis with Candida colonization. |
| format | Article |
| id | doaj-art-e54d90586c364858950f13fa054a5c42 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-e54d90586c364858950f13fa054a5c422025-08-20T03:27:32ZengMDPI AGMicroorganisms2076-26072025-05-01136118110.3390/microorganisms13061181Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU PatientsJames Hurley0Melbourne Medical School, University of Melbourne, Parkville, VIC 3052, Australia<i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, <i>Acinetobacter</i> species, and <i>Candida</i> species are common ventilator-associated pneumonia (VAP) isolates. Whilst the clinical significance of <i>Candida</i> as a VAP isolate is unclear, evidence is emerging that <i>Candida</i> interacts with bacteria, contributing to colonization susceptibility. Indirectly, VAP isolate data reflect patient colonization within cohorts. The objective here is to estimate the association between these three bacteria and Candida as VAP isolates. ICU cohorts were obtained by searching the literature for mechanically ventilated (MV) patient cohorts in which Candida was listed as an isolate among patients with VAP. Regression models of the associated VAP incidence per 100 MV patients, using random effects methods, incorporated group-level factors such as the year of publication, mode of VAP diagnosis, and ICU stay length. The median VAP incidence proportions for <i>Staphylococcus aureus, Pseudomonas aeruginosa,</i> and <i>Acinetobacter</i> species were 3.3 (IQR: 1.2–6.9), 3.6 (IQR: 1.8–5.7), and 1.2 (IQR: 0.4–4.1), respectively. Among 84 cohorts from 67 publications, <i>Staphylococcus aureus</i> (correlation coefficient = 0.759) and <i>Pseudomonas aeruginosa</i> (0.749), and less so <i>Acinetobacter</i> species (0.53)<i>,</i> each show correlation with the isolation of <i>Candida</i> species among these ICU populations. These associations may underlie the poor prognosis with Candida colonization.https://www.mdpi.com/2076-2607/13/6/1181ventilator-associated pneumoniaintensive care unitobservational cohortmechanical ventilation<i>Staphylococcus aureus</i><i>Pseudomonas aeruginosa</i> |
| spellingShingle | James Hurley Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients Microorganisms ventilator-associated pneumonia intensive care unit observational cohort mechanical ventilation <i>Staphylococcus aureus</i> <i>Pseudomonas aeruginosa</i> |
| title | Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients |
| title_full | Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients |
| title_fullStr | Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients |
| title_full_unstemmed | Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients |
| title_short | Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients |
| title_sort | associations between candida and i staphylococcus aureus pseudomonas aeruginosa i and i acinetobacter i species as ventilator associated pneumonia isolates in 84 cohorts of icu patients |
| topic | ventilator-associated pneumonia intensive care unit observational cohort mechanical ventilation <i>Staphylococcus aureus</i> <i>Pseudomonas aeruginosa</i> |
| url | https://www.mdpi.com/2076-2607/13/6/1181 |
| work_keys_str_mv | AT jameshurley associationsbetweencandidaandistaphylococcusaureuspseudomonasaeruginosaiandiacinetobacterispeciesasventilatorassociatedpneumoniaisolatesin84cohortsoficupatients |