Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure
Background/Aim. Patients with chronic renal failure (CRF) have increased cardiovascular morbidity and mortality. It is unknown which biomarkers best describe the degree of diastolic dysfunction in patients with CRF. The aim of this study was to determine the correlation between B-type natri...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2017-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600079P.pdf |
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| author | Petrović Milica Grdinić Aleksandra Bokonjić Dubravko Rabrenović Violeta Antić Svetlana Terzić Brankica Stamenković Dušica Stajić Zoran Petrović Dejan Ignjatović Ljiljana Pejović Janko Jovanović Dragan |
| author_facet | Petrović Milica Grdinić Aleksandra Bokonjić Dubravko Rabrenović Violeta Antić Svetlana Terzić Brankica Stamenković Dušica Stajić Zoran Petrović Dejan Ignjatović Ljiljana Pejović Janko Jovanović Dragan |
| author_sort | Petrović Milica |
| collection | DOAJ |
| description | Background/Aim. Patients with chronic renal failure (CRF) have increased
cardiovascular morbidity and mortality. It is unknown which biomarkers best
describe the degree of diastolic dysfunction in patients with CRF. The aim of
this study was to determine the correlation between B-type natriuretic
peptide (BNP), N-terminal prohormone brain natriuretic peptide (NTproBNP) and
left ventricular diastolic dysfunction (DD-LV) with the degree of CRF.
Methods. The study included 100 adult patients with CRF without major cardiac
and cerebral incidents who did not start actively treating CRF. According to
the degree of CRF, the patients were divided into two groups: G1 (moderate
degree), glomerular filtration rate (GFR) ≥ 30 mL/min/1.73 m2, and G2 (more
severe degree), GFR < 30 mL/min/1.73 m2. Blood concentrations of BNP and
NTproBNP were measured and Doppler echocardiographic measurement performed to
estimate diastolic dysfunction (DD-LV). According to the degree of DD-LV, all
the patients were divided into two groups: DD-LV1 (mild diastolic
dysfunction) and DD-LV2 (severe diastolic dysfunction). According to the
degree of CRF and DD-LV, the patients were divided into four groups: I (G1,
DD-LV1), II (G1, DD-LV2), III (G2, DD-LV1) and IV (G2, DD-LV2). Results.
There was a highly significant statistical correlation between BNP and
NTproBNP with GFR (p < 0.001), and DD-LV with BNP (p < 0.023) and NTproBNP (p
= 0.035). In patients with DD-LV2, a statistically significantly higher BNP
concentrations were registered in patients with G2 (p < 0.001). Unlike BNP in
the patients with diastolic dysfunction DD-LV1 and those with diastolic
dysfunction DD-LV2, significantly higher concentrations of NTproBNP were
registered in the patients with G2 (DD- LV1: p = 0.006; DD-LV2: p < 0.001).
Conclusion. Biomarkers BNP and NTproBNP are not the best predictors in the
assessment of diastolic dysfunction because they are correlated with the
degree of renal insufficiency. |
| format | Article |
| id | doaj-art-e54ce8cf216d4cf88f74532a6b86a14f |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-e54ce8cf216d4cf88f74532a6b86a14f2025-08-20T02:21:19ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202017-01-0174655055510.2298/VSP151019079P0042-84501600079PBlood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failurePetrović Milica0Grdinić Aleksandra1Bokonjić Dubravko2Rabrenović Violeta3Antić Svetlana4Terzić Brankica5Stamenković Dušica6Stajić Zoran7Petrović Dejan8Ignjatović Ljiljana9Pejović Janko10Jovanović Dragan11Military Medical Academy, Clinic of Nephrology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Institute of Medical Biochemistry, BelgradeUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, National Poisoning Control Centre, BelgradeMilitary Medical Academy, Clinic of Nephrology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeMilitary Medical Academy, Clinic of Nephrology, BelgradeMilitary Medical Academy, Clinic of Nephrology, BelgradeMilitary Medical Academy, National Poisoning Control Centre, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Clinic of Anesthesiology and Intensive Therapy, BelgradeUniversity Clinical Center, Clinic of Urology and Nephrology, Kragujevac, SerbiaInstitute for Health Protection of the Ministry of Interior, Department of Internal Medicine, BelgradeMilitary Medical Academy, Clinic of Nephrology, BelgradeUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Institute of Medical Biochemistry, BelgradeMilitary Medical Academy, Clinic of Nephrology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeBackground/Aim. Patients with chronic renal failure (CRF) have increased cardiovascular morbidity and mortality. It is unknown which biomarkers best describe the degree of diastolic dysfunction in patients with CRF. The aim of this study was to determine the correlation between B-type natriuretic peptide (BNP), N-terminal prohormone brain natriuretic peptide (NTproBNP) and left ventricular diastolic dysfunction (DD-LV) with the degree of CRF. Methods. The study included 100 adult patients with CRF without major cardiac and cerebral incidents who did not start actively treating CRF. According to the degree of CRF, the patients were divided into two groups: G1 (moderate degree), glomerular filtration rate (GFR) ≥ 30 mL/min/1.73 m2, and G2 (more severe degree), GFR < 30 mL/min/1.73 m2. Blood concentrations of BNP and NTproBNP were measured and Doppler echocardiographic measurement performed to estimate diastolic dysfunction (DD-LV). According to the degree of DD-LV, all the patients were divided into two groups: DD-LV1 (mild diastolic dysfunction) and DD-LV2 (severe diastolic dysfunction). According to the degree of CRF and DD-LV, the patients were divided into four groups: I (G1, DD-LV1), II (G1, DD-LV2), III (G2, DD-LV1) and IV (G2, DD-LV2). Results. There was a highly significant statistical correlation between BNP and NTproBNP with GFR (p < 0.001), and DD-LV with BNP (p < 0.023) and NTproBNP (p = 0.035). In patients with DD-LV2, a statistically significantly higher BNP concentrations were registered in patients with G2 (p < 0.001). Unlike BNP in the patients with diastolic dysfunction DD-LV1 and those with diastolic dysfunction DD-LV2, significantly higher concentrations of NTproBNP were registered in the patients with G2 (DD- LV1: p = 0.006; DD-LV2: p < 0.001). Conclusion. Biomarkers BNP and NTproBNP are not the best predictors in the assessment of diastolic dysfunction because they are correlated with the degree of renal insufficiency.http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600079P.pdfkidney failure+ chronicglomerular filtration rateventricular function+ leftnatriuretic peptidesbiological makerssensitivity and specificity |
| spellingShingle | Petrović Milica Grdinić Aleksandra Bokonjić Dubravko Rabrenović Violeta Antić Svetlana Terzić Brankica Stamenković Dušica Stajić Zoran Petrović Dejan Ignjatović Ljiljana Pejović Janko Jovanović Dragan Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure Vojnosanitetski Pregled kidney failure+ chronic glomerular filtration rate ventricular function+ left natriuretic peptides biological makers sensitivity and specificity |
| title | Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure |
| title_full | Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure |
| title_fullStr | Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure |
| title_full_unstemmed | Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure |
| title_short | Blood concentrations of B-type natriuretic peptide and N-terminal prohormone B-type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure |
| title_sort | blood concentrations of b type natriuretic peptide and n terminal prohormone b type natriuretic peptide as markers of left ventricle diastolic function in patients with chronic renal failure |
| topic | kidney failure+ chronic glomerular filtration rate ventricular function+ left natriuretic peptides biological makers sensitivity and specificity |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600079P.pdf |
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