C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices
Background/Aim. Measles is a contagious disease with a good prognosis; however, severe complications may sometimes develop. C-reactive protein (CRP) and blood cells count-derived inflammatory indices – granulocyte-lymphocyte ratio (GLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte rat...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2023-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200041S.pdf |
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| author | Stojiljković Marija Miljković Mirjana |
| author_facet | Stojiljković Marija Miljković Mirjana |
| author_sort | Stojiljković Marija |
| collection | DOAJ |
| description | Background/Aim. Measles is a contagious disease with a good prognosis; however, severe complications may sometimes develop. C-reactive protein (CRP) and blood cells count-derived inflammatory indices – granulocyte-lymphocyte ratio (GLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), mean plate-let volume (MPV)/platelet count ratio (MPR), red blood cell distribution width (RDW), and MPV are the indicators related to the clinical outcome in various inflammatory diseases. The aim of the study was to analyze the values of CRP, blood cell count, GLR, PLR, MLR, MPR, RDW, and MPV in measles-affected children compared to healthy controls and between measles-affected children with complicated and severely complicated measles form. A particular aim of the paper was to assess the suitability of inflammatory-derived markers for predicting the severity of the disease. Methods. The study included 55 measles-affected children who developed complications (examination group), while the control group included 30 healthy children. The first peripheral blood count, obtained on the first hospitalization day (before treatment), was used for further analyses. Results. The white blood cells, lymphocytes, monocytes, and platelets count were significantly lower, while GLR, PLR, MPR, and CRP were significantly higher in measles-affected children (p ˂ 0.05). In severely complicated measles form, significantly higher values of granulocytes, CRP, GLR, and PLR were documented, including lower lymphocytes (p ˂ 0.05). A linear regression analysis showed that CRP was the only indicator with predictive significance for the severity of the course of measles. Conclusion. The blood cell count-derived inflammatory indices should not be crucial in assessing the severity of measles in children. CRP was the most valuable predictive factor for the development of the severe course of measles in measles-affected children. |
| format | Article |
| id | doaj-art-e54c8a55c85d433fa27a450ca62e5da0 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-e54c8a55c85d433fa27a450ca62e5da02025-08-20T03:26:20ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202023-01-0180210711410.2298/VSP210820041S0042-84502200041SC-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indicesStojiljković Marija0Miljković Mirjana1General Hospital of Leskovac, Pediatric Department, Leskovac, Serbia + University of Niš, Faculty of Medicine, Niš, SerbiaGeneral Hospital of Leskovac, Pediatric Department, Leskovac, SerbiaBackground/Aim. Measles is a contagious disease with a good prognosis; however, severe complications may sometimes develop. C-reactive protein (CRP) and blood cells count-derived inflammatory indices – granulocyte-lymphocyte ratio (GLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), mean plate-let volume (MPV)/platelet count ratio (MPR), red blood cell distribution width (RDW), and MPV are the indicators related to the clinical outcome in various inflammatory diseases. The aim of the study was to analyze the values of CRP, blood cell count, GLR, PLR, MLR, MPR, RDW, and MPV in measles-affected children compared to healthy controls and between measles-affected children with complicated and severely complicated measles form. A particular aim of the paper was to assess the suitability of inflammatory-derived markers for predicting the severity of the disease. Methods. The study included 55 measles-affected children who developed complications (examination group), while the control group included 30 healthy children. The first peripheral blood count, obtained on the first hospitalization day (before treatment), was used for further analyses. Results. The white blood cells, lymphocytes, monocytes, and platelets count were significantly lower, while GLR, PLR, MPR, and CRP were significantly higher in measles-affected children (p ˂ 0.05). In severely complicated measles form, significantly higher values of granulocytes, CRP, GLR, and PLR were documented, including lower lymphocytes (p ˂ 0.05). A linear regression analysis showed that CRP was the only indicator with predictive significance for the severity of the course of measles. Conclusion. The blood cell count-derived inflammatory indices should not be crucial in assessing the severity of measles in children. CRP was the most valuable predictive factor for the development of the severe course of measles in measles-affected children.https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200041S.pdfblood cellsblood plateletschildc-reactive proteinleukocytesmeaslesprognosisseverity of illness index |
| spellingShingle | Stojiljković Marija Miljković Mirjana C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices Vojnosanitetski Pregled blood cells blood platelets child c-reactive protein leukocytes measles prognosis severity of illness index |
| title | C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices |
| title_full | C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices |
| title_fullStr | C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices |
| title_full_unstemmed | C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices |
| title_short | C-reactive protein is a more valuable marker in predicting the severity of complications in measles-affected children compared to blood cells count-derived inflammatory indices |
| title_sort | c reactive protein is a more valuable marker in predicting the severity of complications in measles affected children compared to blood cells count derived inflammatory indices |
| topic | blood cells blood platelets child c-reactive protein leukocytes measles prognosis severity of illness index |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200041S.pdf |
| work_keys_str_mv | AT stojiljkovicmarija creactiveproteinisamorevaluablemarkerinpredictingtheseverityofcomplicationsinmeaslesaffectedchildrencomparedtobloodcellscountderivedinflammatoryindices AT miljkovicmirjana creactiveproteinisamorevaluablemarkerinpredictingtheseverityofcomplicationsinmeaslesaffectedchildrencomparedtobloodcellscountderivedinflammatoryindices |