Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke

Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke

Abstract Background Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome...

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Bibliographic Details
Main Authors: AbdelRahman Mohamed Hussein, Iman Mohamed Bayoumy, Khaled Ossama Abdulghani, Mona Ali Eissa, Ehab Mostafa Ahmed, Ali Ahmed Abou Elmaaty
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Subjects:
Stroke
Rt-PA
NIHSS
mRS
Thrombolysis functional outcome
Online Access:https://doi.org/10.1186/s41983-024-00931-8
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Summary:Abstract Background Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome following IV rt-PA treatment in a group of Egyptian patients with acute ischemic stroke (AIS). We included sixty patients diagnosed with AIS who met the criteria for IV rt-PA therapy. Data were collected and statistically analyzed, we established correlations with functional outcomes as measured by the modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS) 3-month post-treatment. Results Of the 60 patients, 40 (66.67%) exhibited a favorable functional outcome, while 20 (33.33%) experienced a less favorable outcome. Poor functional outcome was associated with atrial fibrillation [p value < 0.001, odds ratio (OR) 6.28], hypertension (p value = 0.001, OR 3.65), diabetes mellitus (p value 0.009, OR 2.805), and a higher NIHSS at admission (p value = 0.003, OR 8.03). Conclusions Certain factors may affect functional outcome in stroke patients treated with rt-PA therapy. There are strong associations between hypertension, diabetes, atrial fibrillation, post-rt-PA intracerebral hemorrhage (both asymptomatic and symptomatic), specific stroke subtypes, and less favorable functional outcome 3 months after rt-PA administration, as measured by the mRS.
ISSN:1687-8329

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