Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis
OBJECTIVE: To evaluate the clinical features and seizure control of epilepsy related to neurocysticercosis. METHOD: 18 patients with partial epilepsy and neurocysticercosis were treated with albendazol or praziquantel and followed from 3 months to 12 years. We analyzed results from the CSF exam, int...
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Thieme Revinter Publicações
2000-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600006&tlng=en |
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| author | ISABEL CRISTINA DOS SANTOS ELIANE KOBAYASHI TÂNIA MARCHIORI CARDOSO CARLOS ALBERTO MANTOVANI GUERREIRO FERNANDO CENDES |
| author_facet | ISABEL CRISTINA DOS SANTOS ELIANE KOBAYASHI TÂNIA MARCHIORI CARDOSO CARLOS ALBERTO MANTOVANI GUERREIRO FERNANDO CENDES |
| author_sort | ISABEL CRISTINA DOS SANTOS |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate the clinical features and seizure control of epilepsy related to neurocysticercosis. METHOD: 18 patients with partial epilepsy and neurocysticercosis were treated with albendazol or praziquantel and followed from 3 months to 12 years. We analyzed results from the CSF exam, interictal electroencephalogram (EEG), head computerized tomography and/or magnetic resonance imaging. RESULTS: The patients' mean age was 36.4 years. The mean duration of epilepsy was 16 years. 83% patients had simple partial seizures ; 17% had complex partial seizures . All patients underwent routine EEGs: 62% had abnormalities and 38% were normal. A relationship was observed between focal EEG abnormality and the location of cyst in 28% of the patients. The CSF exams showed pleocytosis in 33% of the patients, and 28% had elevated protein levels. Only 22% of patients had positive titer for cysticercosis in the CSF. In all patients who had somatosensory and special sensory seizures there was a relationship between location of the cysts and seizure semiology (n=11). After cysticidal therapy, 83% patients had a significant improvement in controlling seizures. CONCLUSION: In this group, we found a predominance of simple partial seizures and a relationship between somatosensory and special sensory seizures and the location of the cysts. Cysticidal therapy was effective in controlling seizures in these patients and should be considered for patients with partial seizures and semiology related to cyst location. |
| format | Article |
| id | doaj-art-e545e91ef03748c5b8f13d72b18b90b6 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2000-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e545e91ef03748c5b8f13d72b18b90b62025-08-20T02:04:30ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272000-12-0158410141020Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosisISABEL CRISTINA DOS SANTOS0ELIANE KOBAYASHI1TÂNIA MARCHIORI CARDOSO2CARLOS ALBERTO MANTOVANI GUERREIRO3FERNANDO CENDES4State University of CampinasState University of CampinasState University of CampinasState University of CampinasState University of CampinasOBJECTIVE: To evaluate the clinical features and seizure control of epilepsy related to neurocysticercosis. METHOD: 18 patients with partial epilepsy and neurocysticercosis were treated with albendazol or praziquantel and followed from 3 months to 12 years. We analyzed results from the CSF exam, interictal electroencephalogram (EEG), head computerized tomography and/or magnetic resonance imaging. RESULTS: The patients' mean age was 36.4 years. The mean duration of epilepsy was 16 years. 83% patients had simple partial seizures ; 17% had complex partial seizures . All patients underwent routine EEGs: 62% had abnormalities and 38% were normal. A relationship was observed between focal EEG abnormality and the location of cyst in 28% of the patients. The CSF exams showed pleocytosis in 33% of the patients, and 28% had elevated protein levels. Only 22% of patients had positive titer for cysticercosis in the CSF. In all patients who had somatosensory and special sensory seizures there was a relationship between location of the cysts and seizure semiology (n=11). After cysticidal therapy, 83% patients had a significant improvement in controlling seizures. CONCLUSION: In this group, we found a predominance of simple partial seizures and a relationship between somatosensory and special sensory seizures and the location of the cysts. Cysticidal therapy was effective in controlling seizures in these patients and should be considered for patients with partial seizures and semiology related to cyst location.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600006&tlng=enneurocysticercosisalbendazolpraziquantelepilepsypartial seizurescomputerized tomographyEEG |
| spellingShingle | ISABEL CRISTINA DOS SANTOS ELIANE KOBAYASHI TÂNIA MARCHIORI CARDOSO CARLOS ALBERTO MANTOVANI GUERREIRO FERNANDO CENDES Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis Arquivos de Neuro-Psiquiatria neurocysticercosis albendazol praziquantel epilepsy partial seizures computerized tomography EEG |
| title | Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis |
| title_full | Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis |
| title_fullStr | Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis |
| title_full_unstemmed | Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis |
| title_short | Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis |
| title_sort | cysticidal therapy impact on seizure control in epilepsy associated with neurocysticercosis |
| topic | neurocysticercosis albendazol praziquantel epilepsy partial seizures computerized tomography EEG |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600006&tlng=en |
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