Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model
Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecul...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/2081962 |
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| author | Osman Bilgin Gulcicek Ali Solmaz Hakan Yiğitbaş Candas Ercetin Erkan Yavuz Kamil Ozdogan Sinan Arici Asli Kahraman Akkalp Tulin Sarac Fatih Çelebi Atilla Celik |
| author_facet | Osman Bilgin Gulcicek Ali Solmaz Hakan Yiğitbaş Candas Ercetin Erkan Yavuz Kamil Ozdogan Sinan Arici Asli Kahraman Akkalp Tulin Sarac Fatih Çelebi Atilla Celik |
| author_sort | Osman Bilgin Gulcicek |
| collection | DOAJ |
| description | Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods. 24 Wistar-Hannover rats were randomly divided into 4 groups and treated with saline, glutamine, curcumin, and nesfatin-1 after ileogastric anastomosis. After 14 days all rats were euthanized, and blood was collected. En bloc resection of anastomotic part was performed for histopathological examination. Results. PDGF, TGF-β, and VEGF levels and neomucosa formation were higher in glutamine group (p=0.003, p=0.003, and p=0.025). Glutamine promotes the intestinal neomucosa formation on the gastric serosal surface and augments growth factors essential for neomucosa formation on rats. Conclusion. Glutamine may be used in short bowel syndrome for increasing the absorption surface area. But that needs to be determined by adequately powered clinical trials. |
| format | Article |
| id | doaj-art-e541da4d44bc4df28cb571609096b0dc |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e541da4d44bc4df28cb571609096b0dc2025-08-20T02:21:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/20819622081962Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent ModelOsman Bilgin Gulcicek0Ali Solmaz1Hakan Yiğitbaş2Candas Ercetin3Erkan Yavuz4Kamil Ozdogan5Sinan Arici6Asli Kahraman Akkalp7Tulin Sarac8Fatih Çelebi9Atilla Celik10Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of Pathology, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of Biochemistry, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, TurkeyIntroduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods. 24 Wistar-Hannover rats were randomly divided into 4 groups and treated with saline, glutamine, curcumin, and nesfatin-1 after ileogastric anastomosis. After 14 days all rats were euthanized, and blood was collected. En bloc resection of anastomotic part was performed for histopathological examination. Results. PDGF, TGF-β, and VEGF levels and neomucosa formation were higher in glutamine group (p=0.003, p=0.003, and p=0.025). Glutamine promotes the intestinal neomucosa formation on the gastric serosal surface and augments growth factors essential for neomucosa formation on rats. Conclusion. Glutamine may be used in short bowel syndrome for increasing the absorption surface area. But that needs to be determined by adequately powered clinical trials.http://dx.doi.org/10.1155/2016/2081962 |
| spellingShingle | Osman Bilgin Gulcicek Ali Solmaz Hakan Yiğitbaş Candas Ercetin Erkan Yavuz Kamil Ozdogan Sinan Arici Asli Kahraman Akkalp Tulin Sarac Fatih Çelebi Atilla Celik Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model Gastroenterology Research and Practice |
| title | Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model |
| title_full | Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model |
| title_fullStr | Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model |
| title_full_unstemmed | Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model |
| title_short | Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model |
| title_sort | comparison of the effects of glutamine curcumin and nesfatin 1 on the gastric serosal surface neomucosa formation an experimental rodent model |
| url | http://dx.doi.org/10.1155/2016/2081962 |
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