Therapeutic potential of GDF-5 for enhancing tendon regenerative healing
Tendon injury is a common disorder of the musculoskeletal system, with a higher possibility of occurrence in elderly individuals and athletes. After a tendon injury, the tendon suffers from inadequate and slow healing, resulting in the formation of fibrotic scar tissue, ending up with inferior funct...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424000610 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850218861252575232 |
|---|---|
| author | Hanyue Li Yini Li Linmei Xiang Shengyu Luo Yan Zhang Sen Li |
| author_facet | Hanyue Li Yini Li Linmei Xiang Shengyu Luo Yan Zhang Sen Li |
| author_sort | Hanyue Li |
| collection | DOAJ |
| description | Tendon injury is a common disorder of the musculoskeletal system, with a higher possibility of occurrence in elderly individuals and athletes. After a tendon injury, the tendon suffers from inadequate and slow healing, resulting in the formation of fibrotic scar tissue, ending up with inferior functional properties. Therapeutic strategies involving the application of growth factors have been advocated to promote tendon healing. Growth and differentiation-5 (GDF-5) represents one such factor that has shown promising effect on tendon healing in animal models and in vitro cultures. Although promising, these studies are limited as the molecular mechanisms by which GDF-5 exerts its effect remain incompletely understood. Starting from broadly introducing essential elements of current understanding about GDF-5, the present review aims to define the effect of GDF-5 and its possible mechanisms of action in tendon healing. Nevertheless, we still need more in vivo studies to explore dosage, application time and delivery strategy of GDF-5, so as to pave the way for future clinical translation. |
| format | Article |
| id | doaj-art-e53fe812e9cc4cbdb57b57b778d7b63e |
| institution | OA Journals |
| issn | 2352-3204 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-e53fe812e9cc4cbdb57b57b778d7b63e2025-08-20T02:07:34ZengElsevierRegenerative Therapy2352-32042024-06-012629029810.1016/j.reth.2024.03.029Therapeutic potential of GDF-5 for enhancing tendon regenerative healingHanyue Li0Yini Li1Linmei Xiang2Shengyu Luo3Yan Zhang4Sen Li5School of Physical Education, Southwest Medical University, PR ChinaDepartment of Ultrasound, The Affiliated Hospital of Southwest Medical University, Sichuan, PR ChinaDepartment of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou, PR ChinaSchool of Physical Education, Southwest Medical University, PR ChinaLuzhou Vocational and Technical College, PR ChinaDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, PR China; Corresponding author. Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Jiangsu, Nanjing 210000, PR China.Tendon injury is a common disorder of the musculoskeletal system, with a higher possibility of occurrence in elderly individuals and athletes. After a tendon injury, the tendon suffers from inadequate and slow healing, resulting in the formation of fibrotic scar tissue, ending up with inferior functional properties. Therapeutic strategies involving the application of growth factors have been advocated to promote tendon healing. Growth and differentiation-5 (GDF-5) represents one such factor that has shown promising effect on tendon healing in animal models and in vitro cultures. Although promising, these studies are limited as the molecular mechanisms by which GDF-5 exerts its effect remain incompletely understood. Starting from broadly introducing essential elements of current understanding about GDF-5, the present review aims to define the effect of GDF-5 and its possible mechanisms of action in tendon healing. Nevertheless, we still need more in vivo studies to explore dosage, application time and delivery strategy of GDF-5, so as to pave the way for future clinical translation.http://www.sciencedirect.com/science/article/pii/S2352320424000610GDF-5BMP-14CDMP-1Tendon healingTendon repairFunction |
| spellingShingle | Hanyue Li Yini Li Linmei Xiang Shengyu Luo Yan Zhang Sen Li Therapeutic potential of GDF-5 for enhancing tendon regenerative healing Regenerative Therapy GDF-5 BMP-14 CDMP-1 Tendon healing Tendon repair Function |
| title | Therapeutic potential of GDF-5 for enhancing tendon regenerative healing |
| title_full | Therapeutic potential of GDF-5 for enhancing tendon regenerative healing |
| title_fullStr | Therapeutic potential of GDF-5 for enhancing tendon regenerative healing |
| title_full_unstemmed | Therapeutic potential of GDF-5 for enhancing tendon regenerative healing |
| title_short | Therapeutic potential of GDF-5 for enhancing tendon regenerative healing |
| title_sort | therapeutic potential of gdf 5 for enhancing tendon regenerative healing |
| topic | GDF-5 BMP-14 CDMP-1 Tendon healing Tendon repair Function |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424000610 |
| work_keys_str_mv | AT hanyueli therapeuticpotentialofgdf5forenhancingtendonregenerativehealing AT yinili therapeuticpotentialofgdf5forenhancingtendonregenerativehealing AT linmeixiang therapeuticpotentialofgdf5forenhancingtendonregenerativehealing AT shengyuluo therapeuticpotentialofgdf5forenhancingtendonregenerativehealing AT yanzhang therapeuticpotentialofgdf5forenhancingtendonregenerativehealing AT senli therapeuticpotentialofgdf5forenhancingtendonregenerativehealing |