BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway
Introduction: Bisphenol A (BPA) is a widespread environmental pollutant which has serious toxic effects on organisms. One of the crucial trace elements is selenium (Se), whose shortage can harm biological tissues and enhance the toxicity of contaminants, in which apoptosis and autophagy are core eve...
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Elsevier
2025-01-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224000420 |
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| author | Wenying Sun Yutian Lei Zhihui Jiang Kun Wang Huanyi Liu Tong Xu |
| author_facet | Wenying Sun Yutian Lei Zhihui Jiang Kun Wang Huanyi Liu Tong Xu |
| author_sort | Wenying Sun |
| collection | DOAJ |
| description | Introduction: Bisphenol A (BPA) is a widespread environmental pollutant which has serious toxic effects on organisms. One of the crucial trace elements is selenium (Se), whose shortage can harm biological tissues and enhance the toxicity of contaminants, in which apoptosis and autophagy are core events. Objectives: An in vivo model was established to investigate the effects of BPA and low-Se on chicken pancreatic tissue, and identify the possible potential molecular mechanism. Methods: A total of 80 1-day-old broiler chickens (Xinghua Chicken Farm, Harbin, China) were stochastically divided into 4 groups (n = 20/group): Control group, BPA group, low-Se group, and low-Se + BPA group. Pancreatic tissue was collected at day 42 to detect changes in markers. Results: First, the data showed that BPA and low-Se exposure gave rose to structural abnormalities in pancreatic tissue, oxidative stress, mitochondrial dysfunction and homeostasis imbalance, apoptosis and mitophagy. In addition, the co-exposure of BPA and low-Se caused the most serious damage to pancreatic tissue. In terms of mechanism, it was found that apoptosis and mitophagy induced by BPA and low-Se were related to the activation of PTEN/PI3K/AKT/mTOR pathway. Conclusion: In summary, the study found that BPA and low-Se exacerbated mitochondria damage, apoptosis and mitophagy by regulating the PTEN/PI3K/AKT/mTOR pathway. |
| format | Article |
| id | doaj-art-e53fb87024374a859ebde335f2ea3d6d |
| institution | DOAJ |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Journal of Advanced Research |
| spelling | doaj-art-e53fb87024374a859ebde335f2ea3d6d2025-08-20T02:49:44ZengElsevierJournal of Advanced Research2090-12322025-01-0167616910.1016/j.jare.2024.01.029BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathwayWenying Sun0Yutian Lei1Zhihui Jiang2Kun Wang3Huanyi Liu4Tong Xu5College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR ChinaHenan Beiai Natural Product Application and Development Engineering Research Center, Anyang Institute of Technology, Anyang 455000, Henan, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Corresponding author at: College of Veterinary Medicine, Northeast Agricultural University, Number 600, Changjiang Street, Harbin 150030, PR China.Introduction: Bisphenol A (BPA) is a widespread environmental pollutant which has serious toxic effects on organisms. One of the crucial trace elements is selenium (Se), whose shortage can harm biological tissues and enhance the toxicity of contaminants, in which apoptosis and autophagy are core events. Objectives: An in vivo model was established to investigate the effects of BPA and low-Se on chicken pancreatic tissue, and identify the possible potential molecular mechanism. Methods: A total of 80 1-day-old broiler chickens (Xinghua Chicken Farm, Harbin, China) were stochastically divided into 4 groups (n = 20/group): Control group, BPA group, low-Se group, and low-Se + BPA group. Pancreatic tissue was collected at day 42 to detect changes in markers. Results: First, the data showed that BPA and low-Se exposure gave rose to structural abnormalities in pancreatic tissue, oxidative stress, mitochondrial dysfunction and homeostasis imbalance, apoptosis and mitophagy. In addition, the co-exposure of BPA and low-Se caused the most serious damage to pancreatic tissue. In terms of mechanism, it was found that apoptosis and mitophagy induced by BPA and low-Se were related to the activation of PTEN/PI3K/AKT/mTOR pathway. Conclusion: In summary, the study found that BPA and low-Se exacerbated mitochondria damage, apoptosis and mitophagy by regulating the PTEN/PI3K/AKT/mTOR pathway.http://www.sciencedirect.com/science/article/pii/S2090123224000420ApoptosisBisphenol ALow-SeMitophagyPTEN/PI3K/AKT/mTOR |
| spellingShingle | Wenying Sun Yutian Lei Zhihui Jiang Kun Wang Huanyi Liu Tong Xu BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway Journal of Advanced Research Apoptosis Bisphenol A Low-Se Mitophagy PTEN/PI3K/AKT/mTOR |
| title | BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway |
| title_full | BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway |
| title_fullStr | BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway |
| title_full_unstemmed | BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway |
| title_short | BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway |
| title_sort | bpa and low se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the pten pi3k akt mtor pathway |
| topic | Apoptosis Bisphenol A Low-Se Mitophagy PTEN/PI3K/AKT/mTOR |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224000420 |
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