Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region
Aim. To identify population characteristics of the PIK3CA gene mutation among breast cancer patients in the Krasnoyarsk region.Materials and methods. The study included 140 patients with breast cancer with a certain mutation status of the PIK3CA gene, observed at the Krasnoyarsk Regional Clinical On...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2024-07-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1234 |
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| author | A. V. Zyuzyukina E. Yu. Yakunina V. I. Borodulina L. A. Vasilovskaya E. V. Slepov V. A. Komissarova R. A. Zukov |
| author_facet | A. V. Zyuzyukina E. Yu. Yakunina V. I. Borodulina L. A. Vasilovskaya E. V. Slepov V. A. Komissarova R. A. Zukov |
| author_sort | A. V. Zyuzyukina |
| collection | DOAJ |
| description | Aim. To identify population characteristics of the PIK3CA gene mutation among breast cancer patients in the Krasnoyarsk region.Materials and methods. The study included 140 patients with breast cancer with a certain mutation status of the PIK3CA gene, observed at the Krasnoyarsk Regional Clinical Oncology Center named after A.I. Kryzhanovsky. Determination of PIK3CA gene mutations (exons 2, 5, 8, 10 and 21) was carried out using commercial kits on equipment from Roche (Germany). Statistical processing of the obtained data was carried out using Microsoft Excel and Statistica 12 software products. The assessment of the factor of influence on the relapse-free and overall survival was carried out by constructing and comparing Kaplan–Meier curves. The result was considered statistically significant at a significance level of p <0.05.Results and conclusion. The overall frequency of occurrence of PIK3CA gene mutations is 38.6 %. The most common mutations are H1047X (55.4 %) in exon 21 and E545K (27.8 %) in exon 10. The median age of breast cancer patients with mutation status in the PIK3CA gene was 58.9 [49.0; 67.0] years, median time to relapse or progression was 62.2 [27.0; 84.0] months. There were no statistically significant differences in relapse-free survival between the presence and absence of mutations (p = 0.8). The effect of changes in PIK3CA on a decrease in overall survival rates (p = 0.047) in breast cancer patients was shown. |
| format | Article |
| id | doaj-art-e53f64da4966412db9bed72e7ef9fa18 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2024-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-e53f64da4966412db9bed72e7ef9fa182025-08-20T04:00:08ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272024-07-01202485410.17650/1994-4098-2024-16-2-48-54849Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk regionA. V. Zyuzyukina0E. Yu. Yakunina1V. I. Borodulina2L. A. Vasilovskaya3E. V. Slepov4V. A. Komissarova5R. A. Zukov6Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Cancer Center named after A.I. KryzhanovskyKrasnoyarsk Regional Clinical Cancer Center named after A.I. KryzhanovskyKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Health of RussiaKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Health of RussiaKrasnoyarsk Regional Clinical Cancer Center named after A.I. KryzhanovskyKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Cancer Center named after A.I. KryzhanovskyKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Cancer Center named after A.I. KryzhanovskyAim. To identify population characteristics of the PIK3CA gene mutation among breast cancer patients in the Krasnoyarsk region.Materials and methods. The study included 140 patients with breast cancer with a certain mutation status of the PIK3CA gene, observed at the Krasnoyarsk Regional Clinical Oncology Center named after A.I. Kryzhanovsky. Determination of PIK3CA gene mutations (exons 2, 5, 8, 10 and 21) was carried out using commercial kits on equipment from Roche (Germany). Statistical processing of the obtained data was carried out using Microsoft Excel and Statistica 12 software products. The assessment of the factor of influence on the relapse-free and overall survival was carried out by constructing and comparing Kaplan–Meier curves. The result was considered statistically significant at a significance level of p <0.05.Results and conclusion. The overall frequency of occurrence of PIK3CA gene mutations is 38.6 %. The most common mutations are H1047X (55.4 %) in exon 21 and E545K (27.8 %) in exon 10. The median age of breast cancer patients with mutation status in the PIK3CA gene was 58.9 [49.0; 67.0] years, median time to relapse or progression was 62.2 [27.0; 84.0] months. There were no statistically significant differences in relapse-free survival between the presence and absence of mutations (p = 0.8). The effect of changes in PIK3CA on a decrease in overall survival rates (p = 0.047) in breast cancer patients was shown.https://ojrs.abvpress.ru/ojrs/article/view/1234breast cancerpik3ca mutationoverall survivalrelapse-free survival |
| spellingShingle | A. V. Zyuzyukina E. Yu. Yakunina V. I. Borodulina L. A. Vasilovskaya E. V. Slepov V. A. Komissarova R. A. Zukov Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region Опухоли женской репродуктивной системы breast cancer pik3ca mutation overall survival relapse-free survival |
| title | Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region |
| title_full | Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region |
| title_fullStr | Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region |
| title_full_unstemmed | Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region |
| title_short | Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region |
| title_sort | mutations of the pik3ca gene in patients with breast cancer in the krasnoyarsk region |
| topic | breast cancer pik3ca mutation overall survival relapse-free survival |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1234 |
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