Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs

The influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs....

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Main Authors: Wenchen Sun, Linglan Deng, Wanjie Zou, Panting Wei, Shaobin Hao, Huadong Wu, Wei Lu, Yuyong He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Veterinary Science
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Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1620128/full
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author Wenchen Sun
Wenchen Sun
Linglan Deng
Linglan Deng
Wanjie Zou
Wanjie Zou
Panting Wei
Panting Wei
Shaobin Hao
Shaobin Hao
Huadong Wu
Wei Lu
Wei Lu
Yuyong He
Yuyong He
author_facet Wenchen Sun
Wenchen Sun
Linglan Deng
Linglan Deng
Wanjie Zou
Wanjie Zou
Panting Wei
Panting Wei
Shaobin Hao
Shaobin Hao
Huadong Wu
Wei Lu
Wei Lu
Yuyong He
Yuyong He
author_sort Wenchen Sun
collection DOAJ
description The influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs. Compared with pigs supplemented with 0% glycerol, 0% vitamin C and 0% niacinamide, pigs supplemented only with 10% glycerol had higher (p < 0.05) TNF-α concentration, partially hepatic steatosis, higher (p < 0.05) relative abundances of Escherichia_shigella, Prevotellaceae_UCG_003, Lachnospiraceae_XPB1014_group, Coprococcus, Lactococcus and Megamonas, lower (p < 0.05) solute carrier family 7 member 11 (SLC7A11) expression in liver tissue. However, pigs offered the diet with a mixture of 0.06% vitamin C and 0.05% niacinamide had higher (p < 0.05) relative abundance of Faecalibaculum and expression of SLC7A11, lower (p < 0.05) relative abundances of Staphylococcus and Clostridium_sensu_stricto_1 in liver tissue. Supplementation of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide simultaneously to pigs increased (p < 0.05) the ferrous ion level, the relative abundances of Escherichia_Shigella, Lactococcus and Desulfobacterota, the expressions of gene Cryptochrome-1(CRY1) and SLC7A11, but decreased (p < 0.05) the expressions of gene C-reactive protein (CRP) and galactokinase 1 (GALK1) in liver tissue. Supplementation with 0.06% vitamin C and 0.05% niacinamide can alleviate the damage in liver of pigs fed a diet containing 10% glycerol.
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spelling doaj-art-e53e4285acae49c8b3b52d2d229d33a82025-08-20T02:07:46ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-06-011210.3389/fvets.2025.16201281620128Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigsWenchen Sun0Wenchen Sun1Linglan Deng2Linglan Deng3Wanjie Zou4Wanjie Zou5Panting Wei6Panting Wei7Shaobin Hao8Shaobin Hao9Huadong Wu10Wei Lu11Wei Lu12Yuyong He13Yuyong He14Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaJiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaJiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaJiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaJiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaJiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaJiangxi Province Key Laboratory of Animal Nutrition and Feed, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaThe influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs. Compared with pigs supplemented with 0% glycerol, 0% vitamin C and 0% niacinamide, pigs supplemented only with 10% glycerol had higher (p < 0.05) TNF-α concentration, partially hepatic steatosis, higher (p < 0.05) relative abundances of Escherichia_shigella, Prevotellaceae_UCG_003, Lachnospiraceae_XPB1014_group, Coprococcus, Lactococcus and Megamonas, lower (p < 0.05) solute carrier family 7 member 11 (SLC7A11) expression in liver tissue. However, pigs offered the diet with a mixture of 0.06% vitamin C and 0.05% niacinamide had higher (p < 0.05) relative abundance of Faecalibaculum and expression of SLC7A11, lower (p < 0.05) relative abundances of Staphylococcus and Clostridium_sensu_stricto_1 in liver tissue. Supplementation of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide simultaneously to pigs increased (p < 0.05) the ferrous ion level, the relative abundances of Escherichia_Shigella, Lactococcus and Desulfobacterota, the expressions of gene Cryptochrome-1(CRY1) and SLC7A11, but decreased (p < 0.05) the expressions of gene C-reactive protein (CRP) and galactokinase 1 (GALK1) in liver tissue. Supplementation with 0.06% vitamin C and 0.05% niacinamide can alleviate the damage in liver of pigs fed a diet containing 10% glycerol.https://www.frontiersin.org/articles/10.3389/fvets.2025.1620128/fulllivermicrobiotaRNA sequencehistomorphologyglycerolvitamins
spellingShingle Wenchen Sun
Wenchen Sun
Linglan Deng
Linglan Deng
Wanjie Zou
Wanjie Zou
Panting Wei
Panting Wei
Shaobin Hao
Shaobin Hao
Huadong Wu
Wei Lu
Wei Lu
Yuyong He
Yuyong He
Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs
Frontiers in Veterinary Science
liver
microbiota
RNA sequence
histomorphology
glycerol
vitamins
title Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs
title_full Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs
title_fullStr Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs
title_full_unstemmed Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs
title_short Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs
title_sort effects of dietary glycerol vitamin c and niacinamide supplementation on liver of growing finishing pigs
topic liver
microbiota
RNA sequence
histomorphology
glycerol
vitamins
url https://www.frontiersin.org/articles/10.3389/fvets.2025.1620128/full
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