A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement
Eosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential risk of end-organ damage associated with it. Giv...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
|
| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=752;epage=755;aulast=Moothedath |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849720948556562432 |
|---|---|
| author | Abdul Wajid Moothedath Debasish Sahoo Rachna Seth Jagdish Prasad Meena Aditya Kumar Gupta |
| author_facet | Abdul Wajid Moothedath Debasish Sahoo Rachna Seth Jagdish Prasad Meena Aditya Kumar Gupta |
| author_sort | Abdul Wajid Moothedath |
| collection | DOAJ |
| description | Eosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential risk of end-organ damage associated with it. Given the broad differential diagnoses of eosinophilia, it is essential to have a systematic approach to the evaluation of unexplained eosinophilia in children. Here, we discuss the case of a 2-year-old child who presented with very high eosinophil counts. A systematic workup of the case helped us in arriving at a rare diagnosis of platelet-derived growth factor receptor-beta (PDGFRB)-rearranged clonal eosinophilia. Identification of such an entity is important as it has therapeutic implications, and early recognition helps in preventing associated end-organ damage by instituting appropriate therapy. Such cases of eosinophilia associated with platelet-derived growth factor receptor-alpha and PDGFRB rearrangement respond dramatically to imatinib. |
| format | Article |
| id | doaj-art-e537b8dc372a4cec980a21f34a6bd01a |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-e537b8dc372a4cec980a21f34a6bd01a2025-08-20T03:11:49ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292020-01-0141575275510.4103/ijmpo.ijmpo_259_20A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangementAbdul Wajid MoothedathDebasish SahooRachna SethJagdish Prasad MeenaAditya Kumar GuptaEosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential risk of end-organ damage associated with it. Given the broad differential diagnoses of eosinophilia, it is essential to have a systematic approach to the evaluation of unexplained eosinophilia in children. Here, we discuss the case of a 2-year-old child who presented with very high eosinophil counts. A systematic workup of the case helped us in arriving at a rare diagnosis of platelet-derived growth factor receptor-beta (PDGFRB)-rearranged clonal eosinophilia. Identification of such an entity is important as it has therapeutic implications, and early recognition helps in preventing associated end-organ damage by instituting appropriate therapy. Such cases of eosinophilia associated with platelet-derived growth factor receptor-alpha and PDGFRB rearrangement respond dramatically to imatinib.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=752;epage=755;aulast=Moothedathchildreneosinophiliahypereosinophiliaimatinibplatelet-derived growth factor receptor-beta |
| spellingShingle | Abdul Wajid Moothedath Debasish Sahoo Rachna Seth Jagdish Prasad Meena Aditya Kumar Gupta A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement Indian Journal of Medical and Paediatric Oncology children eosinophilia hypereosinophilia imatinib platelet-derived growth factor receptor-beta |
| title | A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement |
| title_full | A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement |
| title_fullStr | A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement |
| title_full_unstemmed | A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement |
| title_short | A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement |
| title_sort | report of an unusual case of pediatric eosinophilia associated with platelet derived growth factor receptor beta rearrangement |
| topic | children eosinophilia hypereosinophilia imatinib platelet-derived growth factor receptor-beta |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=752;epage=755;aulast=Moothedath |
| work_keys_str_mv | AT abdulwajidmoothedath areportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT debasishsahoo areportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT rachnaseth areportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT jagdishprasadmeena areportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT adityakumargupta areportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT abdulwajidmoothedath reportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT debasishsahoo reportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT rachnaseth reportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT jagdishprasadmeena reportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement AT adityakumargupta reportofanunusualcaseofpediatriceosinophiliaassociatedwithplateletderivedgrowthfactorreceptorbetarearrangement |