Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

Abstract GBM is an aggressive primary malignant brain tumor that has a poor prognosis. Molecular characterization of GBM has shown that EGFR mutations are present in over 50% of tumors. However, EGFR inhibitors have not shown clinical efficacy in contrast to other EGFR-driven neoplasms due to the un...

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Main Authors: Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari, C. Ryan Miller
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
EGFR
Glioblastoma
Synthetic lethality
Kin­ome rewiring
Upfront combinatorial therapy
Online Access:https://doi.org/10.1186/s40478-025-02068-y
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