Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive growth factor used in oral and maxillofacial surgery. It offers a feasible alternative for various regenerative procedures, including reconstruction of mandibular defects. In this study, we report a case of a large Pindbor...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2020/8281741 |
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| author | Kamel Alraei Jameel Sharqawi Somaya Harcher Ibrahim Ghita |
| author_facet | Kamel Alraei Jameel Sharqawi Somaya Harcher Ibrahim Ghita |
| author_sort | Kamel Alraei |
| collection | DOAJ |
| description | Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive growth factor used in oral and maxillofacial surgery. It offers a feasible alternative for various regenerative procedures, including reconstruction of mandibular defects. In this study, we report a case of a large Pindborg tumor involving the left mandible. The treatment consisted of surgical resection, followed by off-label use of rhBMP-2 in addition to bone marrow aspirate concentrate, together with an allograft in a titanium mesh. The patient was rehabilitated with dental implants, and a good clinical outcome was achieved. We found no evidence of bone resorption or complications in both clinical and radiographic evaluations during the one-year follow-up period. In conclusion, we have demonstrated the efficacy of using rhBMP-2 combined with bone marrow aspirate concentrate, and an allograft with a titanium mesh, for the reconstruction of long mandibular bone defects. Not only is this combination feasible, but it also has the advantages of lower morbidity and cost. |
| format | Article |
| id | doaj-art-e535bd6de4e84cefa373af05d7714757 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-e535bd6de4e84cefa373af05d77147572025-08-20T03:26:20ZengWileyCase Reports in Dentistry2090-64472090-64552020-01-01202010.1155/2020/82817418281741Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor ResectionKamel Alraei0Jameel Sharqawi1Somaya Harcher2Ibrahim Ghita3Department of Oral and Maxillofacial Surgery, Al-Noor Specialist Hospital, Makkah, Saudi ArabiaDepartment of Oral and Maxillofacial Surgery, Royal Commission Hospital, Jubail, Saudi ArabiaGeneral Dentist, Saudi ArabiaDepartment of Hematology, Al-Noor Specialist Hospital, Makkah, Saudi ArabiaRecombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive growth factor used in oral and maxillofacial surgery. It offers a feasible alternative for various regenerative procedures, including reconstruction of mandibular defects. In this study, we report a case of a large Pindborg tumor involving the left mandible. The treatment consisted of surgical resection, followed by off-label use of rhBMP-2 in addition to bone marrow aspirate concentrate, together with an allograft in a titanium mesh. The patient was rehabilitated with dental implants, and a good clinical outcome was achieved. We found no evidence of bone resorption or complications in both clinical and radiographic evaluations during the one-year follow-up period. In conclusion, we have demonstrated the efficacy of using rhBMP-2 combined with bone marrow aspirate concentrate, and an allograft with a titanium mesh, for the reconstruction of long mandibular bone defects. Not only is this combination feasible, but it also has the advantages of lower morbidity and cost.http://dx.doi.org/10.1155/2020/8281741 |
| spellingShingle | Kamel Alraei Jameel Sharqawi Somaya Harcher Ibrahim Ghita Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection Case Reports in Dentistry |
| title | Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection |
| title_full | Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection |
| title_fullStr | Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection |
| title_full_unstemmed | Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection |
| title_short | Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection |
| title_sort | efficacy of the combination of rhbmp 2 with bone marrow aspirate concentrate in mandibular defect reconstruction after a pindborg tumor resection |
| url | http://dx.doi.org/10.1155/2020/8281741 |
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