T cell toxicity induced by tigecycline binding to the mitochondrial ribosome

T cell toxicity induced by tigecycline binding to the mitochondrial ribosome

Abstract Tetracyclines are essential bacterial protein synthesis inhibitors under continual development to combat antibiotic resistance yet suffer from unwanted side effects. Mitoribosomes - responsible for generating oxidative phosphorylation (OXPHOS) subunits - share structural similarities with b...

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Main Authors: Qiuya Shao, Anas Khawaja, Minh Duc Nguyen, Vivek Singh, Jingdian Zhang, Yong Liu, Joel Nordin, Monika Adori, C. Axel Innis, Xaquin Castro Dopico, Joanna Rorbach
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59388-9
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