Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery
Strokes causing similar lesions and clinical states can be followed by diverse regains of neurological functions, indicating that the clinical recovery can depend on individual modulating factors. A promising line to disclose these factors, to finally open new therapeutic strategies, is to search fo...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/1971875 |
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| author | Filippo Zappasodi Patrizio Pasqualetti Paolo M. Rossini Franca Tecchio |
| author_facet | Filippo Zappasodi Patrizio Pasqualetti Paolo M. Rossini Franca Tecchio |
| author_sort | Filippo Zappasodi |
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| description | Strokes causing similar lesions and clinical states can be followed by diverse regains of neurological functions, indicating that the clinical recovery can depend on individual modulating factors. A promising line to disclose these factors, to finally open new therapeutic strategies, is to search for individual indices of recovery prognosis. Here, we pursued on strengthening the value of acute phase electrophysiological biomarkers for poststroke functional recovery in a wide group of patients. We enrolled 120 patients affected by a monohemispheric stroke within the middle cerebral artery territory (70 left and 50 right damages) and collected the NIH stroke scale (NIHSS) score in the acute phase (T0, median 4 days) and chronic follow-up (T1, median 6 months). At T0, we executed electrophysiological noninvasive assessment (19-channel electroencephalography (EEG) or 28 channels per side magnetoencephalography (MEG)) of brain activity at rest by means of band powers in the contra- and ipsilesional hemispheres (CLH, ILH) or the homologous area symmetry (HArS). Low-band (2-6 Hz) HArS entered the regression model for predicting the stabilized clinical state (p<0.001), with bilateral impairment correlated with a poor outcome. Present data strengthen the fact that low-band impairment of homologous ipsi- and contralesional hemispheric regions in the acute stroke indicate a negative prognosis of clinical recovery. |
| format | Article |
| id | doaj-art-e5305c8b0e1b445eb04fd4f993c748cf |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e5305c8b0e1b445eb04fd4f993c748cf2025-08-20T02:21:19ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/19718751971875Acute Phase Neuronal Activity for the Prognosis of Stroke RecoveryFilippo Zappasodi0Patrizio Pasqualetti1Paolo M. Rossini2Franca Tecchio3Department of Neuroscience, Imaging and Clinical Sciences, “G. d’Annunzio” University of Chieti, Chieti 66100, ItalyMedical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome 00186, ItalyInstitute of Neurology, Department of Geriatrics, Neurosciences & Orthopaedics, Catholic University of Sacred Heart, Rome 00168, ItalyLaboratory of Electrophysiology for Translational neuroScience (LET’S)-ISTC-CNR, Rome 00185, ItalyStrokes causing similar lesions and clinical states can be followed by diverse regains of neurological functions, indicating that the clinical recovery can depend on individual modulating factors. A promising line to disclose these factors, to finally open new therapeutic strategies, is to search for individual indices of recovery prognosis. Here, we pursued on strengthening the value of acute phase electrophysiological biomarkers for poststroke functional recovery in a wide group of patients. We enrolled 120 patients affected by a monohemispheric stroke within the middle cerebral artery territory (70 left and 50 right damages) and collected the NIH stroke scale (NIHSS) score in the acute phase (T0, median 4 days) and chronic follow-up (T1, median 6 months). At T0, we executed electrophysiological noninvasive assessment (19-channel electroencephalography (EEG) or 28 channels per side magnetoencephalography (MEG)) of brain activity at rest by means of band powers in the contra- and ipsilesional hemispheres (CLH, ILH) or the homologous area symmetry (HArS). Low-band (2-6 Hz) HArS entered the regression model for predicting the stabilized clinical state (p<0.001), with bilateral impairment correlated with a poor outcome. Present data strengthen the fact that low-band impairment of homologous ipsi- and contralesional hemispheric regions in the acute stroke indicate a negative prognosis of clinical recovery.http://dx.doi.org/10.1155/2019/1971875 |
| spellingShingle | Filippo Zappasodi Patrizio Pasqualetti Paolo M. Rossini Franca Tecchio Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery Neural Plasticity |
| title | Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery |
| title_full | Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery |
| title_fullStr | Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery |
| title_full_unstemmed | Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery |
| title_short | Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery |
| title_sort | acute phase neuronal activity for the prognosis of stroke recovery |
| url | http://dx.doi.org/10.1155/2019/1971875 |
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