Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters
The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6423637 |
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| author | Yuanyuan Luo Hua Qu Hang Wang Huili Wei Jing Wu Yang Duan Dan Liu Huacong Deng |
| author_facet | Yuanyuan Luo Hua Qu Hang Wang Huili Wei Jing Wu Yang Duan Dan Liu Huacong Deng |
| author_sort | Yuanyuan Luo |
| collection | DOAJ |
| description | The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P<0.01). Patients with both OB and T2DM had the highest periostin levels. Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P<0.05 or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.001). Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P<0.001). These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels. Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance. |
| format | Article |
| id | doaj-art-e52fbd7fc10c4f6a8c0599dbf23222d3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e52fbd7fc10c4f6a8c0599dbf23222d32025-02-03T07:24:29ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/64236376423637Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid ParametersYuanyuan Luo0Hua Qu1Hang Wang2Huili Wei3Jing Wu4Yang Duan5Dan Liu6Huacong Deng7Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaThe purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P<0.01). Patients with both OB and T2DM had the highest periostin levels. Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P<0.05 or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.001). Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P<0.001). These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels. Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.http://dx.doi.org/10.1155/2016/6423637 |
| spellingShingle | Yuanyuan Luo Hua Qu Hang Wang Huili Wei Jing Wu Yang Duan Dan Liu Huacong Deng Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters Mediators of Inflammation |
| title | Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters |
| title_full | Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters |
| title_fullStr | Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters |
| title_full_unstemmed | Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters |
| title_short | Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters |
| title_sort | plasma periostin levels are increased in chinese subjects with obesity and type 2 diabetes and are positively correlated with glucose and lipid parameters |
| url | http://dx.doi.org/10.1155/2016/6423637 |
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