An immune-based predictive model for HBV clearance: validation in multicenter cohorts and mechanistic insights from in vivo studies
Abstract Background Chronic HBV infection is a major risk factor for hepatocellular carcinoma, posing a significant global health burden. However, predictive models for HBV clearance based on immune biomarkers remain limited. Methods We systematically developed a predictive tool by quantifying mRNA...
Saved in:
| Main Authors: | Rongzheng Zhang, Han Qiao, Kun Zhou, Xiaomei Ju, Xinyang Cao, Jianming Dong, Meng Wu, Le Yu, Shuyun Zhang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Virology Journal |
| Online Access: | https://doi.org/10.1186/s12985-025-02792-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Comprehensive Analysis of m7G-Related Genes and Chronic Hepatitis B: Diagnostic Markers, Immune Microenvironment Regulation, Disease Progression
by: Rongzheng Zhang, et al.
Published: (2023-01-01) -
Mechanistic in vitro–in vivo extrapolation (IVIVE) approach using a biomimetic in vitro system for the prediction of hepatic clearance
by: Seongwon Park, et al.
Published: (2025-01-01) -
HBV reactivation and prognosis after systemic therapy in HCC with undetectable HBV DNA: a multicenter retrospective study
by: Zhipeng Liang, et al.
Published: (2025-08-01) -
HBV reactivation and its management in HBV-related HCC patients undergoing HAIC-TKI-ICI therapy: A multicenter study
by: Jiayun Liu, et al.
Published: (2025-06-01) -
Reevaluating antiviral thresholds in HBV DNA-negative inactive HBsAg carriers: a multicenter histopathological analysis
by: Shan Ren, et al.
Published: (2025-07-01)