Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination
Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilat...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2015/690891 |
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| author | Eriko Nakamura Yuichiro Sato Sayaka Moriguchi Atsushi Yamashita Takashi Higo Yujiro Asada |
| author_facet | Eriko Nakamura Yuichiro Sato Sayaka Moriguchi Atsushi Yamashita Takashi Higo Yujiro Asada |
| author_sort | Eriko Nakamura |
| collection | DOAJ |
| description | Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. There was no transitional lesion between the two tumors. Immunohistochemistry showed different staining patterns in tumor components. Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. Clear cell tumor cells were positive for Napsin A and p504S and focally positive for HNF1B but negative for ER and PgR. Loss of ARID1A expression was not observed in SMBTs, clear cell tumors, or endometriosis. These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature. |
| format | Article |
| id | doaj-art-e52f05f869f14669a1dcf791e9ccb475 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-e52f05f869f14669a1dcf791e9ccb4752025-02-03T06:13:51ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922015-01-01201510.1155/2015/690891690891Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual CombinationEriko Nakamura0Yuichiro Sato1Sayaka Moriguchi2Atsushi Yamashita3Takashi Higo4Yujiro Asada5Department of Pathology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Diagnostic Pathology, Miyazaki University Hospital, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Diagnostic Pathology, Miyazaki University Hospital, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Pathology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Gynecology and Obstetrics, Koga Hospital, 1749-1 Sudaki, Ikeuchi, Miyazaki 880-0041, JapanDepartment of Pathology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanOvarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. There was no transitional lesion between the two tumors. Immunohistochemistry showed different staining patterns in tumor components. Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. Clear cell tumor cells were positive for Napsin A and p504S and focally positive for HNF1B but negative for ER and PgR. Loss of ARID1A expression was not observed in SMBTs, clear cell tumors, or endometriosis. These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature.http://dx.doi.org/10.1155/2015/690891 |
| spellingShingle | Eriko Nakamura Yuichiro Sato Sayaka Moriguchi Atsushi Yamashita Takashi Higo Yujiro Asada Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination Case Reports in Obstetrics and Gynecology |
| title | Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination |
| title_full | Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination |
| title_fullStr | Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination |
| title_full_unstemmed | Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination |
| title_short | Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination |
| title_sort | ovarian seromucinous borderline tumor and clear cell carcinoma an unusual combination |
| url | http://dx.doi.org/10.1155/2015/690891 |
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