Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits
This study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapat...
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MDPI AG
2024-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/12/375 |
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| author | Gustavo Augusto Grossi-Oliveira Eduardo Dallazen Thabet Asbi João Matheus Fonseca-Santos Paulo Domingos Ribeiro-Júnior Jamil A. Shibli Cinthya Massari Grecco Osvaldo Magro-Filho Carlos Fernando Mourão Doron Haim Yaniv Mayer Leonardo P. Faverani |
| author_facet | Gustavo Augusto Grossi-Oliveira Eduardo Dallazen Thabet Asbi João Matheus Fonseca-Santos Paulo Domingos Ribeiro-Júnior Jamil A. Shibli Cinthya Massari Grecco Osvaldo Magro-Filho Carlos Fernando Mourão Doron Haim Yaniv Mayer Leonardo P. Faverani |
| author_sort | Gustavo Augusto Grossi-Oliveira |
| collection | DOAJ |
| description | This study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapatite (HA) from bovine bone, HA combined with PRF, and PRF alone. Each group consisted of five animals (n = 5). A histological analysis measured bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). The results showed significant increases in the BIC and BAFO values at 40 days compared to 14 days in most groups. At day 14, the HA+PRF group had higher BIC than the clot and the PRF alone groups. At 40 days, HA+PRF maintained the highest BIC across all groups (<i>p</i> < 0.05), though it did not show an advantage for BAFO. These findings indicate that combining HA with PRF promotes better osseointegration around implants placed immediately in maxillary sinus augmentation. Given the limited research on PRF’s biological impact, these results underscore the importance of evaluating PRF’s role in peri-implant healing and its potential benefits for clinical use in sinus augmentation. |
| format | Article |
| id | doaj-art-e52814d2723f4bcc9276f6c99551a5a7 |
| institution | DOAJ |
| issn | 2079-4983 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-e52814d2723f4bcc9276f6c99551a5a72025-08-20T02:55:41ZengMDPI AGJournal of Functional Biomaterials2079-49832024-12-01151237510.3390/jfb15120375Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in RabbitsGustavo Augusto Grossi-Oliveira0Eduardo Dallazen1Thabet Asbi2João Matheus Fonseca-Santos3Paulo Domingos Ribeiro-Júnior4Jamil A. Shibli5Cinthya Massari Grecco6Osvaldo Magro-Filho7Carlos Fernando Mourão8Doron Haim9Yaniv Mayer10Leonardo P. Faverani11Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilDepartment of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilMaccabi-Dent Research Department, Tel-Aviv 6801298, IsraelDepartment of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilDivision of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, UNISAGRADO, Bauru 17011-160, SP, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDepartment of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilDepartment of Basic and Clinical Translational Sciences, School of Dental Medicine, Tufts University, Boston, MA 02111, USAMaccabi-Dent Research Department, Tel-Aviv 6801298, IsraelDepartment of Periodontology, Rambam Health Care Campus, Haifa 3525408, IsraelDepartment of Oral Diagnosis, Division of Oral and Maxillofacial Surgery, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, BrazilThis study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapatite (HA) from bovine bone, HA combined with PRF, and PRF alone. Each group consisted of five animals (n = 5). A histological analysis measured bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). The results showed significant increases in the BIC and BAFO values at 40 days compared to 14 days in most groups. At day 14, the HA+PRF group had higher BIC than the clot and the PRF alone groups. At 40 days, HA+PRF maintained the highest BIC across all groups (<i>p</i> < 0.05), though it did not show an advantage for BAFO. These findings indicate that combining HA with PRF promotes better osseointegration around implants placed immediately in maxillary sinus augmentation. Given the limited research on PRF’s biological impact, these results underscore the importance of evaluating PRF’s role in peri-implant healing and its potential benefits for clinical use in sinus augmentation.https://www.mdpi.com/2079-4983/15/12/375alveolar bone lossbone substitutesplatelet-rich fibrindental implants |
| spellingShingle | Gustavo Augusto Grossi-Oliveira Eduardo Dallazen Thabet Asbi João Matheus Fonseca-Santos Paulo Domingos Ribeiro-Júnior Jamil A. Shibli Cinthya Massari Grecco Osvaldo Magro-Filho Carlos Fernando Mourão Doron Haim Yaniv Mayer Leonardo P. Faverani Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits Journal of Functional Biomaterials alveolar bone loss bone substitutes platelet-rich fibrin dental implants |
| title | Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits |
| title_full | Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits |
| title_fullStr | Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits |
| title_full_unstemmed | Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits |
| title_short | Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits |
| title_sort | effects of platelet rich fibrin on bone healing around implants placed in maxillary sinuses a histomorphometric assessment in rabbits |
| topic | alveolar bone loss bone substitutes platelet-rich fibrin dental implants |
| url | https://www.mdpi.com/2079-4983/15/12/375 |
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