Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications
Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, pyroptosis acts as a double‐edged sword, making it important to optimize the design strategies of functional materials t...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202500873 |
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| _version_ | 1850155651730243584 |
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| author | Luyao Tian Shuo Piao Xia Li Lanping Guo Luqi Huang Wenyuan Gao |
| author_facet | Luyao Tian Shuo Piao Xia Li Lanping Guo Luqi Huang Wenyuan Gao |
| author_sort | Luyao Tian |
| collection | DOAJ |
| description | Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, pyroptosis acts as a double‐edged sword, making it important to optimize the design strategies of functional materials to appropriately activate pyroptosis for effective disease treatment. This paper summarizes and discusses the structure, pore formation, and molecular mechanisms of “executor” Gasdermins, as well as the events preceding and following these processes. Subsequently, the focus is on reviewing functional materials that directly regulate Gasdermin pore formation to target pyroptosis and those that indirectly regulate the events before and after Gasdermin pore formation to control pyroptosis activity. Finally, the advantages, disadvantages, and future prospects of designing such functional materials are provided, aiming to facilitate the precise design, pharmacological investigation, and clinical translation of pyroptosis‐related functional materials. |
| format | Article |
| id | doaj-art-e5252996ff734d4b9d12bf22d527ae55 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-e5252996ff734d4b9d12bf22d527ae552025-08-20T02:24:50ZengWileyAdvanced Science2198-38442025-04-011216n/an/a10.1002/advs.202500873Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and ApplicationsLuyao Tian0Shuo Piao1Xia Li2Lanping Guo3Luqi Huang4Wenyuan Gao5School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. ChinaSchool of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. ChinaSchool of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. ChinaNational Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 P. R. ChinaNational Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 P. R. ChinaKey Laboratory of Pharmacology School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. ChinaAbstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, pyroptosis acts as a double‐edged sword, making it important to optimize the design strategies of functional materials to appropriately activate pyroptosis for effective disease treatment. This paper summarizes and discusses the structure, pore formation, and molecular mechanisms of “executor” Gasdermins, as well as the events preceding and following these processes. Subsequently, the focus is on reviewing functional materials that directly regulate Gasdermin pore formation to target pyroptosis and those that indirectly regulate the events before and after Gasdermin pore formation to control pyroptosis activity. Finally, the advantages, disadvantages, and future prospects of designing such functional materials are provided, aiming to facilitate the precise design, pharmacological investigation, and clinical translation of pyroptosis‐related functional materials.https://doi.org/10.1002/advs.202500873functionalities and applicationsfunctional materialgasderminimmune lanscapepyroptosis |
| spellingShingle | Luyao Tian Shuo Piao Xia Li Lanping Guo Luqi Huang Wenyuan Gao Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications Advanced Science functionalities and applications functional material gasdermin immune lanscape pyroptosis |
| title | Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications |
| title_full | Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications |
| title_fullStr | Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications |
| title_full_unstemmed | Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications |
| title_short | Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications |
| title_sort | functional materials targeted regulation of gasdermins from fundamentals to functionalities and applications |
| topic | functionalities and applications functional material gasdermin immune lanscape pyroptosis |
| url | https://doi.org/10.1002/advs.202500873 |
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