Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1
Aim: to demonstrate the clinical picture and the tactics of differential diagnosis between ulcerative colitis and Clostridium difficile-associated disease in a patient with APS-1, as well as to describe the tactics of managing such patients.Key findings. A 25-year-old patient with autoimmune polygla...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2019-03-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/331 |
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| author | Elizaveta A. Trush Alexander V. Korolev Elena A. Poluektova Pavel V. Pavlov Maria G. Pavlova Alexander S. Tertychny Yulia O. Sidorina Natalia A. Ponkratova Oleg S. Shifrin |
| author_facet | Elizaveta A. Trush Alexander V. Korolev Elena A. Poluektova Pavel V. Pavlov Maria G. Pavlova Alexander S. Tertychny Yulia O. Sidorina Natalia A. Ponkratova Oleg S. Shifrin |
| author_sort | Elizaveta A. Trush |
| collection | DOAJ |
| description | Aim: to demonstrate the clinical picture and the tactics of differential diagnosis between ulcerative colitis and Clostridium difficile-associated disease in a patient with APS-1, as well as to describe the tactics of managing such patients.Key findings. A 25-year-old patient with autoimmune polyglandular syndrome type 1 (APS-1) complained of loose stools up to 10 times a day with blood admixture, rapidly growing weakness and a weight loss of 5 kg per week. When examined on the day of admission, surgical pathology was excluded. Further differential diagnostics between Clostridium difficile-associated disease and ulcerative colitis was carried out, with the possibility of combining these diseases being not excluded. The examination confirmed Clostridium difficile-associated disease, while the diagnosis of ulcerative colitis needed further verification. APS-1 is often combined with other diseases and is likely to be pathogenetically related with them; however, the mechanisms of such interrelations still remain unknown. Previous research has reported the relationship between APS-1 and clostridial infection. The combination of ulcerative colitis with APS-1 has not thus far been described.Conclusion. A specific feature of the described clinical case consists in the development of severe Clostridium difficile-associated disease against the background of autoimmune polyglandular syndrome type 1. The management of patients with APS-1 should take into account the possibility of developing a clostridial infection, since these diseases can co-occur. When treating a patient with APS-1 in non-endocrine hospital units, consultation with an endocrinologist is necessary. |
| format | Article |
| id | doaj-art-e523959fc50940f49b0ac52506900eec |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-e523959fc50940f49b0ac52506900eec2025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732019-03-01291778410.22416/1382-4376-2019-29-1-93-100289Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1Elizaveta A. Trush0Alexander V. Korolev1Elena A. Poluektova2Pavel V. Pavlov3Maria G. Pavlova4Alexander S. Tertychny5Yulia O. Sidorina6Natalia A. Ponkratova7Oleg S. Shifrin8I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim: to demonstrate the clinical picture and the tactics of differential diagnosis between ulcerative colitis and Clostridium difficile-associated disease in a patient with APS-1, as well as to describe the tactics of managing such patients.Key findings. A 25-year-old patient with autoimmune polyglandular syndrome type 1 (APS-1) complained of loose stools up to 10 times a day with blood admixture, rapidly growing weakness and a weight loss of 5 kg per week. When examined on the day of admission, surgical pathology was excluded. Further differential diagnostics between Clostridium difficile-associated disease and ulcerative colitis was carried out, with the possibility of combining these diseases being not excluded. The examination confirmed Clostridium difficile-associated disease, while the diagnosis of ulcerative colitis needed further verification. APS-1 is often combined with other diseases and is likely to be pathogenetically related with them; however, the mechanisms of such interrelations still remain unknown. Previous research has reported the relationship between APS-1 and clostridial infection. The combination of ulcerative colitis with APS-1 has not thus far been described.Conclusion. A specific feature of the described clinical case consists in the development of severe Clostridium difficile-associated disease against the background of autoimmune polyglandular syndrome type 1. The management of patients with APS-1 should take into account the possibility of developing a clostridial infection, since these diseases can co-occur. When treating a patient with APS-1 in non-endocrine hospital units, consultation with an endocrinologist is necessary.https://www.gastro-j.ru/jour/article/view/331autoimmune polyglandular syndrome type 1clostridium difficile-associated diseaseulcerative colitisdifferential diagnosis |
| spellingShingle | Elizaveta A. Trush Alexander V. Korolev Elena A. Poluektova Pavel V. Pavlov Maria G. Pavlova Alexander S. Tertychny Yulia O. Sidorina Natalia A. Ponkratova Oleg S. Shifrin Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1 Российский журнал гастроэнтерологии, гепатологии, колопроктологии autoimmune polyglandular syndrome type 1 clostridium difficile-associated disease ulcerative colitis differential diagnosis |
| title | Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1 |
| title_full | Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1 |
| title_fullStr | Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1 |
| title_full_unstemmed | Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1 |
| title_short | Differential Diagnosis between Ulcerative Colitis and Clostridium Difficile-Associated Disease in a Patient with Autoimmune Polyglandular Syndrome Type 1 |
| title_sort | differential diagnosis between ulcerative colitis and clostridium difficile associated disease in a patient with autoimmune polyglandular syndrome type 1 |
| topic | autoimmune polyglandular syndrome type 1 clostridium difficile-associated disease ulcerative colitis differential diagnosis |
| url | https://www.gastro-j.ru/jour/article/view/331 |
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