Ferritin and C-Reactive Protein: The Key Outcome Predictors in Patients with Coronavirus Disease and Severe Kidney Disease
Background: Coronavirus Disease 2019 (COVID 19) pandemic affected the kidneys in many ways. Presence of kidney disease in COVID patients was associated with high mortality and morbidity. In this study, we examined whether Ferritin and C-Reactive protien(CRP) levels at admission in patients with seve...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Indian Journal of Kidney Diseases |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijkd.ijkd_14_23 |
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| Summary: | Background:
Coronavirus Disease 2019 (COVID 19) pandemic affected the kidneys in many ways. Presence of kidney disease in COVID patients was associated with high mortality and morbidity. In this study, we examined whether Ferritin and C-Reactive protien(CRP) levels at admission in patients with severe COVID predicted the outcome in such patients requiring haemodialysis (HD) support for kidney disease.
Materials and Methods:
A retrospective analysis of 126 patients admitted with severe COVID who underwent haemodialysis was done. Ferritin and CRP levels at admission were compared in survivors and non survivors with COVID.
Results:
A total of 126 individuals, 60 with acute kidney injury (AKI) and 66 with chronic kidney disease (CKD) were included in the study. The CKD group had 35 survivors compared to 13 survivors in the AKI group. In the AKI group, the mean ages of survivors and nonsurvivors were 46.85 ± 14.62 and 60.34 ± 15.06 years (P < 0.001). In the CKD group, the mean ages of survivors and nonsurvivors were 43.77 ± 13.60 and 54.48 ± 14.20 years (P = 0.003). Ferritin levels in the survivors and nonsurvivors in the AKI group were 626.55 ± 303.49 ng/mL and 999.92 ± 274.54 ng/mL (P < 0.001); in the survivors and nonsurvivors in the CKD group, they were 320.72 ± 308.83 ng/mL and 996.00 ± 347.94 ng/mL (P < 0.001). CRP level was 74.71 ± 88.16 mg/L and 202.56 ± 92.95 mg/L in survivors and nonsurvivors (P < 0.001) in the AKI group; 33.92 ± 26.91 mg/L and 192.98 ± 81.81 mg/L in survivors and nonsurvivors (P < 0.001) in the CKD group.
Conclusion:
Our study strongly suggests that, irrespective of the acute or chronic status of renal injury, high levels of ferritin and CRP at presentation are invariably associated with poor outcomes in COVID patients intervened with hemodialysis and should be taken into consideration for early decision-making while initiating renal replacement therapy. |
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| ISSN: | 2950-0761 |