Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets
Abstract Cancer, characterized by its immune evasion, active metabolism, and heightened proliferation, comprises both stroma and cells. Although the research has always focused on parenchymal cells, the non-parenchymal components must not be overlooked. Targeting cancer parenchymal cells has proven...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Molecular Biomedicine |
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| Online Access: | https://doi.org/10.1186/s43556-024-00233-8 |
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| author | Keke Lv Tianlin He |
| author_facet | Keke Lv Tianlin He |
| author_sort | Keke Lv |
| collection | DOAJ |
| description | Abstract Cancer, characterized by its immune evasion, active metabolism, and heightened proliferation, comprises both stroma and cells. Although the research has always focused on parenchymal cells, the non-parenchymal components must not be overlooked. Targeting cancer parenchymal cells has proven to be a formidable challenge, yielding limited success on a broad scale. The tumor microenvironment(TME), a critical niche for cancer cell survival, presents a novel way for cancer treatment. Cancer-associated fibroblast (CAF), as a main component of TME, is a dynamically evolving, dual-functioning stromal cell. Furthermore, their biological activities span the entire spectrum of tumor development, metastasis, drug resistance, and prognosis. A thorough understanding of CAFs functions and therapeutic advances holds significant clinical implications. In this review, we underscore the heterogeneity of CAFs by elaborating on their origins, types and function. Most importantly, by elucidating the direct or indirect crosstalk between CAFs and immune cells, the extracellular matrix, and cancer cells, we emphasize the tumorigenicity of CAFs in cancer. Finally, we highlight the challenges encountered in the exploration of CAFs and list targeted therapies for CAF, which have implications for clinical treatment. |
| format | Article |
| id | doaj-art-e51a95648b7948d687ede2e474660410 |
| institution | DOAJ |
| issn | 2662-8651 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Molecular Biomedicine |
| spelling | doaj-art-e51a95648b7948d687ede2e4746604102025-08-20T02:39:54ZengSpringerMolecular Biomedicine2662-86512024-12-015112210.1186/s43556-024-00233-8Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targetsKeke Lv0Tianlin He1Department of Hepatopanreatobiliary Surgery, Changhai HospitalDepartment of Hepatopanreatobiliary Surgery, Changhai HospitalAbstract Cancer, characterized by its immune evasion, active metabolism, and heightened proliferation, comprises both stroma and cells. Although the research has always focused on parenchymal cells, the non-parenchymal components must not be overlooked. Targeting cancer parenchymal cells has proven to be a formidable challenge, yielding limited success on a broad scale. The tumor microenvironment(TME), a critical niche for cancer cell survival, presents a novel way for cancer treatment. Cancer-associated fibroblast (CAF), as a main component of TME, is a dynamically evolving, dual-functioning stromal cell. Furthermore, their biological activities span the entire spectrum of tumor development, metastasis, drug resistance, and prognosis. A thorough understanding of CAFs functions and therapeutic advances holds significant clinical implications. In this review, we underscore the heterogeneity of CAFs by elaborating on their origins, types and function. Most importantly, by elucidating the direct or indirect crosstalk between CAFs and immune cells, the extracellular matrix, and cancer cells, we emphasize the tumorigenicity of CAFs in cancer. Finally, we highlight the challenges encountered in the exploration of CAFs and list targeted therapies for CAF, which have implications for clinical treatment.https://doi.org/10.1186/s43556-024-00233-8Cancer associated fibroblastsTumor microenvironmentExtracellular matrixImmune cellsMechanismsCancer cell |
| spellingShingle | Keke Lv Tianlin He Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets Molecular Biomedicine Cancer associated fibroblasts Tumor microenvironment Extracellular matrix Immune cells Mechanisms Cancer cell |
| title | Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets |
| title_full | Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets |
| title_fullStr | Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets |
| title_full_unstemmed | Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets |
| title_short | Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets |
| title_sort | cancer associated fibroblasts heterogeneity tumorigenicity and therapeutic targets |
| topic | Cancer associated fibroblasts Tumor microenvironment Extracellular matrix Immune cells Mechanisms Cancer cell |
| url | https://doi.org/10.1186/s43556-024-00233-8 |
| work_keys_str_mv | AT kekelv cancerassociatedfibroblastsheterogeneitytumorigenicityandtherapeutictargets AT tianlinhe cancerassociatedfibroblastsheterogeneitytumorigenicityandtherapeutictargets |