Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies
The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-11-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S205647242400766X/type/journal_article |
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| author | Gemma Greenfinch Calum A. Hamilton Paul C. Donaghy Michael Firbank Nicola A. Barnett Louise Allan George S. Petrides John-Paul Taylor John T. O'Brien Alan J. Thomas |
| author_facet | Gemma Greenfinch Calum A. Hamilton Paul C. Donaghy Michael Firbank Nicola A. Barnett Louise Allan George S. Petrides John-Paul Taylor John T. O'Brien Alan J. Thomas |
| author_sort | Gemma Greenfinch |
| collection | DOAJ |
| description | The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was −5.2% (range: −23.8% to +7.0%). The interpolated mean annual change in uptake was −1.6%. |
| format | Article |
| id | doaj-art-e519faefdb544755935a18184234e2cc |
| institution | OA Journals |
| issn | 2056-4724 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-e519faefdb544755935a18184234e2cc2025-08-20T02:19:11ZengCambridge University PressBJPsych Open2056-47242024-11-011010.1192/bjo.2024.766Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodiesGemma Greenfinch0https://orcid.org/0000-0002-6445-4023Calum A. Hamilton1https://orcid.org/0000-0002-9812-3150Paul C. Donaghy2Michael Firbank3Nicola A. Barnett4Louise Allan5George S. Petrides6John-Paul Taylor7John T. O'Brien8https://orcid.org/0000-0002-0837-5080Alan J. Thomas9Newcastle University Translational and Clinical Research Institute, Newcastle, UK; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; and University College London Hospital, London, UKNewcastle University Translational and Clinical Research Institute, Newcastle, UKNewcastle University Translational and Clinical Research Institute, Newcastle, UKNewcastle University Translational and Clinical Research Institute, Newcastle, UKNewcastle University Translational and Clinical Research Institute, Newcastle, UKUniversity of Exeter Medical School, Exeter, UKNuclear Medicine Department, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKNewcastle University Translational and Clinical Research Institute, Newcastle, UKUniversity of Cambridge School of Clinical Medicine, Cambridge, UKNewcastle University Translational and Clinical Research Institute, Newcastle, UKThe aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was −5.2% (range: −23.8% to +7.0%). The interpolated mean annual change in uptake was −1.6%.https://www.cambridge.org/core/product/identifier/S205647242400766X/type/journal_articleCardiac mIBGsympathetic innervationDLBMCI-LBLewy body disease |
| spellingShingle | Gemma Greenfinch Calum A. Hamilton Paul C. Donaghy Michael Firbank Nicola A. Barnett Louise Allan George S. Petrides John-Paul Taylor John T. O'Brien Alan J. Thomas Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies BJPsych Open Cardiac mIBG sympathetic innervation DLB MCI-LB Lewy body disease |
| title | Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies |
| title_full | Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies |
| title_fullStr | Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies |
| title_full_unstemmed | Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies |
| title_short | Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies |
| title_sort | longitudinal changes in cardiac mibg scintigraphy in mild cognitive impairment with lewy bodies |
| topic | Cardiac mIBG sympathetic innervation DLB MCI-LB Lewy body disease |
| url | https://www.cambridge.org/core/product/identifier/S205647242400766X/type/journal_article |
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