Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review
Abstract In the field of liver disease treatment, liver transplantation (LT) has become an effective option for end-stage liver disease. However, issues such as immune rejection and graft damage remain important factors influencing the success rate of liver transplantation and patients' quality...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-025-02911-y |
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| author | Yiwu Zhong Xu Hu Xiaoping Li Yinbiao Qiao Haoyu Li Shijie Zhou Shusen Zheng Jianhui Li |
| author_facet | Yiwu Zhong Xu Hu Xiaoping Li Yinbiao Qiao Haoyu Li Shijie Zhou Shusen Zheng Jianhui Li |
| author_sort | Yiwu Zhong |
| collection | DOAJ |
| description | Abstract In the field of liver disease treatment, liver transplantation (LT) has become an effective option for end-stage liver disease. However, issues such as immune rejection and graft damage remain important factors influencing the success rate of liver transplantation and patients' quality of life. In recent years, with the advancement of genetic testing technologies, the study and application of donor-derived cell-free DNA (dd-cfDNA) in LT diagnosis and treatment have gradually gained attention. This review explores the research advancements in dd-cfDNA within liver transplant management, evaluating its potential applications throughout the liver transplantation process, while exploring the challenges faced by current studies and outlining future research directions. As a strategic tool for postoperative monitoring in LT, dd-cfDNA shows promising potential in areas such as immune rejection, graft damage, immunosuppressant adjustment, complication monitoring, and personalized treatment, and is poised to become a reliable biomarker in LT management. |
| format | Article |
| id | doaj-art-e519e86c6f9e4e2696fbba47141febae |
| institution | Kabale University |
| issn | 1471-2482 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj-art-e519e86c6f9e4e2696fbba47141febae2025-08-20T03:53:57ZengBMCBMC Surgery1471-24822025-05-0125111110.1186/s12893-025-02911-yAdvances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative reviewYiwu Zhong0Xu Hu1Xiaoping Li2Yinbiao Qiao3Haoyu Li4Shijie Zhou5Shusen Zheng6Jianhui Li7Zhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren UniversityNHC Key Laboratory of Combined Multi-Organ TransplantationNHC Key Laboratory of Combined Multi-Organ TransplantationNHC Key Laboratory of Combined Multi-Organ TransplantationNHC Key Laboratory of Combined Multi-Organ TransplantationKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren UniversityAbstract In the field of liver disease treatment, liver transplantation (LT) has become an effective option for end-stage liver disease. However, issues such as immune rejection and graft damage remain important factors influencing the success rate of liver transplantation and patients' quality of life. In recent years, with the advancement of genetic testing technologies, the study and application of donor-derived cell-free DNA (dd-cfDNA) in LT diagnosis and treatment have gradually gained attention. This review explores the research advancements in dd-cfDNA within liver transplant management, evaluating its potential applications throughout the liver transplantation process, while exploring the challenges faced by current studies and outlining future research directions. As a strategic tool for postoperative monitoring in LT, dd-cfDNA shows promising potential in areas such as immune rejection, graft damage, immunosuppressant adjustment, complication monitoring, and personalized treatment, and is poised to become a reliable biomarker in LT management.https://doi.org/10.1186/s12893-025-02911-yDonor-derived cell-free DNABiomarkersLiver transplantationNon-invasive MonitoringTransplant monitoring |
| spellingShingle | Yiwu Zhong Xu Hu Xiaoping Li Yinbiao Qiao Haoyu Li Shijie Zhou Shusen Zheng Jianhui Li Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review BMC Surgery Donor-derived cell-free DNA Biomarkers Liver transplantation Non-invasive Monitoring Transplant monitoring |
| title | Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review |
| title_full | Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review |
| title_fullStr | Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review |
| title_full_unstemmed | Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review |
| title_short | Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review |
| title_sort | advances and challenges in the application of donor derived cell free dna for diagnosis and treatment in liver transplantation a narrative review |
| topic | Donor-derived cell-free DNA Biomarkers Liver transplantation Non-invasive Monitoring Transplant monitoring |
| url | https://doi.org/10.1186/s12893-025-02911-y |
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