The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma
Background. Esophageal cancer (EC), as a serious threat to human life and health, is one of the most common cancers around the world. Many studies have suggested that many microRNAs are involved in tumorigenesis and progression. Methods. To search for a novel and promising predictive therapeutic tar...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/3420946 |
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| _version_ | 1849435339599380480 |
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| author | Hongfei Cai Yang Li Da Qin Rui Wang Ze Tang Tianyu Lu Youbin Cui |
| author_facet | Hongfei Cai Yang Li Da Qin Rui Wang Ze Tang Tianyu Lu Youbin Cui |
| author_sort | Hongfei Cai |
| collection | DOAJ |
| description | Background. Esophageal cancer (EC), as a serious threat to human life and health, is one of the most common cancers around the world. Many studies have suggested that many microRNAs are involved in tumorigenesis and progression. Methods. To search for a novel and promising predictive therapeutic target or biomarker to achieve the goal of the early diagnosis and treatment of EC, we used the EC cell lines Eca-109 and KYSE-150 and normal human esophageal epithelial cells (HEECs) to investigate the effect of ABI3BP on EC. Results. We found that ABI family member 3 binding protein (ABI3BP) was downregulated in EC and suppressed the proliferation, activity, migration, and invasion of EC cells. ABI3BP was downregulated by miR-183, which plays the role of an oncogene. Conclusion. ABI3BP and miR-183 can be considered potential biomarkers for the diagnosis of patients with EC and can be effective targets for antitumor therapy. |
| format | Article |
| id | doaj-art-e5195e7a66004afbae31433d170b6ab9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e5195e7a66004afbae31433d170b6ab92025-08-20T03:26:20ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/34209463420946The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal CarcinomaHongfei Cai0Yang Li1Da Qin2Rui Wang3Ze Tang4Tianyu Lu5Youbin Cui6Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaBackground. Esophageal cancer (EC), as a serious threat to human life and health, is one of the most common cancers around the world. Many studies have suggested that many microRNAs are involved in tumorigenesis and progression. Methods. To search for a novel and promising predictive therapeutic target or biomarker to achieve the goal of the early diagnosis and treatment of EC, we used the EC cell lines Eca-109 and KYSE-150 and normal human esophageal epithelial cells (HEECs) to investigate the effect of ABI3BP on EC. Results. We found that ABI family member 3 binding protein (ABI3BP) was downregulated in EC and suppressed the proliferation, activity, migration, and invasion of EC cells. ABI3BP was downregulated by miR-183, which plays the role of an oncogene. Conclusion. ABI3BP and miR-183 can be considered potential biomarkers for the diagnosis of patients with EC and can be effective targets for antitumor therapy.http://dx.doi.org/10.1155/2020/3420946 |
| spellingShingle | Hongfei Cai Yang Li Da Qin Rui Wang Ze Tang Tianyu Lu Youbin Cui The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma Mediators of Inflammation |
| title | The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma |
| title_full | The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma |
| title_fullStr | The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma |
| title_full_unstemmed | The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma |
| title_short | The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma |
| title_sort | depletion of abi3bp by microrna 183 promotes the development of esophageal carcinoma |
| url | http://dx.doi.org/10.1155/2020/3420946 |
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