Association between dietary inflammatory index and epilepsy: findings from NHANES
BackgroundInflammation plays a crucial role in the onset and progression of epilepsy. However, there is limited information regarding the relationship between diet-related inflammation and epilepsy. This study aimed to investigate the association between dietary inflammatory index (DII) and epilepsy...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1599286/full |
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| author | Yike Zhu Chuansen Lu |
| author_facet | Yike Zhu Chuansen Lu |
| author_sort | Yike Zhu |
| collection | DOAJ |
| description | BackgroundInflammation plays a crucial role in the onset and progression of epilepsy. However, there is limited information regarding the relationship between diet-related inflammation and epilepsy. This study aimed to investigate the association between dietary inflammatory index (DII) and epilepsy.MethodsWe conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2020. The DII scores were calculated and categorized into quartiles. Logistic regression was applied to assess the association between DII and epilepsy. Additionally, restricted cubic spline (RCS) analysis and subgroup analyses were performed.ResultsThe study included a total of 10,761 participants. After adjusting for age, gender, race, body mass index (BMI), smoking status, alcohol consumption, stroke, diabetes, and hypertension, a significant positive association was observed between DII and epilepsy in multivariable logistic regression (quartile 4 vs. 1, OR = 2.66, 95% CI 1.66–4.28, p < 0.001). The RCS analysis further confirmed a positive linear relationship between increasing DII scores and epilepsy risk (p for overall = 0.0007, p for nonlinear = 0.5128). Subgroup analyses showed a consistent association between DII and epilepsy across different subgroups.ConclusionElevated DII scores are associated with the risk of epilepsy. To improve epilepsy prevention and management, attention to dietary inflammation regulation is essential. |
| format | Article |
| id | doaj-art-e51516c33ed540daa7a4bbe73c686bf4 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-e51516c33ed540daa7a4bbe73c686bf42025-08-20T03:05:46ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15992861599286Association between dietary inflammatory index and epilepsy: findings from NHANESYike Zhu0Chuansen Lu1Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaBackgroundInflammation plays a crucial role in the onset and progression of epilepsy. However, there is limited information regarding the relationship between diet-related inflammation and epilepsy. This study aimed to investigate the association between dietary inflammatory index (DII) and epilepsy.MethodsWe conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2020. The DII scores were calculated and categorized into quartiles. Logistic regression was applied to assess the association between DII and epilepsy. Additionally, restricted cubic spline (RCS) analysis and subgroup analyses were performed.ResultsThe study included a total of 10,761 participants. After adjusting for age, gender, race, body mass index (BMI), smoking status, alcohol consumption, stroke, diabetes, and hypertension, a significant positive association was observed between DII and epilepsy in multivariable logistic regression (quartile 4 vs. 1, OR = 2.66, 95% CI 1.66–4.28, p < 0.001). The RCS analysis further confirmed a positive linear relationship between increasing DII scores and epilepsy risk (p for overall = 0.0007, p for nonlinear = 0.5128). Subgroup analyses showed a consistent association between DII and epilepsy across different subgroups.ConclusionElevated DII scores are associated with the risk of epilepsy. To improve epilepsy prevention and management, attention to dietary inflammation regulation is essential.https://www.frontiersin.org/articles/10.3389/fneur.2025.1599286/fullNHANESDIIepilepsycross-sectional studydiet |
| spellingShingle | Yike Zhu Chuansen Lu Association between dietary inflammatory index and epilepsy: findings from NHANES Frontiers in Neurology NHANES DII epilepsy cross-sectional study diet |
| title | Association between dietary inflammatory index and epilepsy: findings from NHANES |
| title_full | Association between dietary inflammatory index and epilepsy: findings from NHANES |
| title_fullStr | Association between dietary inflammatory index and epilepsy: findings from NHANES |
| title_full_unstemmed | Association between dietary inflammatory index and epilepsy: findings from NHANES |
| title_short | Association between dietary inflammatory index and epilepsy: findings from NHANES |
| title_sort | association between dietary inflammatory index and epilepsy findings from nhanes |
| topic | NHANES DII epilepsy cross-sectional study diet |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1599286/full |
| work_keys_str_mv | AT yikezhu associationbetweendietaryinflammatoryindexandepilepsyfindingsfromnhanes AT chuansenlu associationbetweendietaryinflammatoryindexandepilepsyfindingsfromnhanes |