Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease

Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease

Alzheimer's disease (AD) is a common neurodegenerative disorder among the elderly, and BuChE has emerged as a potential therapeutic target. In this study, we reported the development of compound 8e, a selective reversible BuChE inhibitor (eqBuChE IC50 = 0.049 μmol/L, huBuChE IC50 = 0.066 μmol/L...

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Bibliographic Details
Main Authors: Zhipei Sang, Shuheng Huang, Wanying Tan, Yujuan Ban, Keren Wang, Yufan Fan, Hongsong Chen, Qiyao Zhang, Chanchan Liang, Jing Mi, Yunqi Gao, Ya Zhang, Wenmin Liu, Jianta Wang, Wu Dong, Zhenghuai Tan, Lei Tang, Haibin Luo
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Alzheimer's disease
Selective BuChE inhibitor
Pharmacokinetic studies
Pharmacodynamic studies
Mechanism of action
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001078
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