TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease

TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease

IntroductionTriggering receptor expressed on myeloid cells-2 (TREM2) variants have been identified as risk factors for neurodegenerative disease, including Alzheimer’s disease. TREM2 is a cell surface receptor on microglia that regulates homeostatic and immunomodulatory functions, including phagocyt...

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Bibliographic Details
Main Authors: Sarah M. Carpanini, Barry M. Bradford, Alessio Alfieri, Pedro Piccardo, Jimena Monzón-Sandoval, Deborah Brown, Aileen Boyle, Aleksandra Pokrovskaya, Neil A. Mabbott, Jean Manson, Barry W. McColl
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Neuroscience
Subjects:
TREM2
neurodegenerative disease
microglial reactivity
pathology
prion disease
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1525017/full
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