RNA Binding Protein YTHDF2 Inhibits Synovial Fibroblast Inflammation and Bone Injury in Rheumatoid Arthritis by Reducing the mRNA Stability of IL‐6R

RNA Binding Protein YTHDF2 Inhibits Synovial Fibroblast Inflammation and Bone Injury in Rheumatoid Arthritis by Reducing the mRNA Stability of IL‐6R

ABSTRACT This study examined YTHDF2's role in modulating IL‐6R signaling to regulate synovial fibroblast inflammation and bone damage in rheumatoid arthritis (RA). Synovial tissues of RA patients were collected. Human fibroblast‐like synoviocyte (FLS), MH7A cell line, was induced with TNF‐α and...

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Main Authors: Yan Zhang, Xu‐Qing Cao, Xiao‐Li Ma, Yin‐Yan Guo, Tao Zhang, Li‐Li Wu, Ya‐Shan Yang, Chun‐Fang Hao, Wei‐Li Liu, Jiang‐Tao Guo
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
fibroblast‐like synoviocytes
IL‐6R
inflammation
rheumatoid arthritis
YTHDF2
Online Access:https://doi.org/10.1002/kjm2.70010
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