Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China
Background Animal studies suggest cardiovascular systems may be primary targets for barium toxicity. This study aims to examine longitudinal associations of prenatal and early childhood barium exposure with cardiometabolic risk (CMR) in preschoolers. Methods and Results We determined serum or plasma...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.037887 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850123493370232832 |
|---|---|
| author | Juan Tong Xing Wang Hong Gan Hui Gao Mengjuan Lu Jixing Zhou Chunmei Liang Shuman Tao Menglong Geng Shuangqin Yan Guopeng Gao Xueqing Wang Kun Huang Xiaoyan Wu Fangbiao Tao |
| author_facet | Juan Tong Xing Wang Hong Gan Hui Gao Mengjuan Lu Jixing Zhou Chunmei Liang Shuman Tao Menglong Geng Shuangqin Yan Guopeng Gao Xueqing Wang Kun Huang Xiaoyan Wu Fangbiao Tao |
| author_sort | Juan Tong |
| collection | DOAJ |
| description | Background Animal studies suggest cardiovascular systems may be primary targets for barium toxicity. This study aims to examine longitudinal associations of prenatal and early childhood barium exposure with cardiometabolic risk (CMR) in preschoolers. Methods and Results We determined serum or plasma barium concentrations during 3 trimesters, delivery, and early childhood (5 years) from 2291 mother–child dyads within the Ma'anshan Birth Cohort. CMR scores were calculated by summing standardized z scores for glucose, insulin, triglycerides, waist circumference, mean of blood pressure, and high‐density lipoprotein cholesterol among 5‐year‐old children. We employed multiple linear regression and multiple informant models to investigate whole pregnancy and stage‐specific associations of barium exposure with CMR scores and individual components and the modifying effects of sex. The ranges of log10‐transformed barium from the first trimester to early childhood were 3.39 to 4.61 ng/L. Barium during the whole pregnancy showed positive associations with CMR scores, glucose, and triglycerides and negative association with high‐density lipoprotein cholesterol. These significant relationships of barium with CMR scores were mainly manifested in the second and third trimesters. Positive associations were observed between barium during the second and third trimesters and CMR scores, glucose, triglycerides, and negatively associated with high‐density lipoprotein cholesterol among boys. In girls, positive associations of barium during the third trimester with CMR scores, glucose, and triglycerides and a negative association with high‐density lipoprotein cholesterol were detected. Conclusions Barium exposure during pregnancy, especially during the second and third trimesters, may increase CMR in preschoolers. Boys are more vulnerable than girls. These findings support the need for reductions in barium exposure during pregnancy. |
| format | Article |
| id | doaj-art-e50d2e919b9948eba39b33c5f30b47bd |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-e50d2e919b9948eba39b33c5f30b47bd2025-08-20T02:34:35ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-03-0114610.1161/JAHA.124.037887Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in ChinaJuan Tong0Xing Wang1Hong Gan2Hui Gao3Mengjuan Lu4Jixing Zhou5Chunmei Liang6Shuman Tao7Menglong Geng8Shuangqin Yan9Guopeng Gao10Xueqing Wang11Kun Huang12Xiaoyan Wu13Fangbiao Tao14Department of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaMa’anshan Maternal and Child Health Care Hospital Ma’anshan Anhui ChinaMa’anshan Maternal and Child Health Care Hospital Ma’anshan Anhui ChinaMa’anshan Maternal and Child Health Care Hospital Ma’anshan Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui ChinaBackground Animal studies suggest cardiovascular systems may be primary targets for barium toxicity. This study aims to examine longitudinal associations of prenatal and early childhood barium exposure with cardiometabolic risk (CMR) in preschoolers. Methods and Results We determined serum or plasma barium concentrations during 3 trimesters, delivery, and early childhood (5 years) from 2291 mother–child dyads within the Ma'anshan Birth Cohort. CMR scores were calculated by summing standardized z scores for glucose, insulin, triglycerides, waist circumference, mean of blood pressure, and high‐density lipoprotein cholesterol among 5‐year‐old children. We employed multiple linear regression and multiple informant models to investigate whole pregnancy and stage‐specific associations of barium exposure with CMR scores and individual components and the modifying effects of sex. The ranges of log10‐transformed barium from the first trimester to early childhood were 3.39 to 4.61 ng/L. Barium during the whole pregnancy showed positive associations with CMR scores, glucose, and triglycerides and negative association with high‐density lipoprotein cholesterol. These significant relationships of barium with CMR scores were mainly manifested in the second and third trimesters. Positive associations were observed between barium during the second and third trimesters and CMR scores, glucose, triglycerides, and negatively associated with high‐density lipoprotein cholesterol among boys. In girls, positive associations of barium during the third trimester with CMR scores, glucose, and triglycerides and a negative association with high‐density lipoprotein cholesterol were detected. Conclusions Barium exposure during pregnancy, especially during the second and third trimesters, may increase CMR in preschoolers. Boys are more vulnerable than girls. These findings support the need for reductions in barium exposure during pregnancy.https://www.ahajournals.org/doi/10.1161/JAHA.124.037887bariumcardiometabolic riskcohortearly‐childhoodprenatal |
| spellingShingle | Juan Tong Xing Wang Hong Gan Hui Gao Mengjuan Lu Jixing Zhou Chunmei Liang Shuman Tao Menglong Geng Shuangqin Yan Guopeng Gao Xueqing Wang Kun Huang Xiaoyan Wu Fangbiao Tao Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease barium cardiometabolic risk cohort early‐childhood prenatal |
| title | Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China |
| title_full | Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China |
| title_fullStr | Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China |
| title_full_unstemmed | Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China |
| title_short | Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma’anshan Birth Cohort Study in China |
| title_sort | gestational and early childhood exposure to barium and cardiometabolic risk in preschoolers findings from the ma anshan birth cohort study in china |
| topic | barium cardiometabolic risk cohort early‐childhood prenatal |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.037887 |
| work_keys_str_mv | AT juantong gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT xingwang gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT honggan gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT huigao gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT mengjuanlu gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT jixingzhou gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT chunmeiliang gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT shumantao gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT menglonggeng gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT shuangqinyan gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT guopenggao gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT xueqingwang gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT kunhuang gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT xiaoyanwu gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina AT fangbiaotao gestationalandearlychildhoodexposuretobariumandcardiometabolicriskinpreschoolersfindingsfromthemaanshanbirthcohortstudyinchina |