Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties
Breast cancer was the most common cancer in women in 157 countries out of 185 in 2022. Therefore, its prognosis and treatment are the concern of many researchers. On the other hand, the synthesis of nanocomposite based on clay and its ability to be used in the field of cancer treatment and drug deli...
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025009491 |
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| author | Masoud Pourrahim Leila Zolghadr |
| author_facet | Masoud Pourrahim Leila Zolghadr |
| author_sort | Masoud Pourrahim |
| collection | DOAJ |
| description | Breast cancer was the most common cancer in women in 157 countries out of 185 in 2022. Therefore, its prognosis and treatment are the concern of many researchers. On the other hand, the synthesis of nanocomposite based on clay and its ability to be used in the field of cancer treatment and drug delivery has always been attractive and is being developed. In this study, the effect of inducing apoptosis based on synthesized magnetite clay-based for introducing a high-potential nano carrier for breast cancer was investigated. Synthesis of nano-carriers was based on three types of modified clay nano colloids) CbNC), magnetite (MNC) and clay-based magnetite nano carriers (MCbNC). The physicochemical properties of the synthesized samples were investigated by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), thermal analysis (TGA) and energy X-ray analysis (EDX). Also, flow cytometry and MTT were used to investigate the induction of apoptosis and toxicity, respectively. In this study, the physicochemical properties of the compounds after surface modification were improved compared to other studies, and the MCbNC compound showed anticancer and apoptosis-inducing properties (96 %) at a lower concentration (IC50,500 μM) than the other two compounds. |
| format | Article |
| id | doaj-art-e509015d4a204d8fafde7339320d8712 |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj-art-e509015d4a204d8fafde7339320d87122025-08-20T02:15:47ZengElsevierHeliyon2405-84402025-02-01114e4256910.1016/j.heliyon.2025.e42569Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical propertiesMasoud Pourrahim0Leila Zolghadr1Technology Units of Imam Khomeini International University of Qazvin, IranDepartment of Chemistry, Imam Khomeini International University, Qazvin, Iran; Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran; Corresponding author: Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran.Breast cancer was the most common cancer in women in 157 countries out of 185 in 2022. Therefore, its prognosis and treatment are the concern of many researchers. On the other hand, the synthesis of nanocomposite based on clay and its ability to be used in the field of cancer treatment and drug delivery has always been attractive and is being developed. In this study, the effect of inducing apoptosis based on synthesized magnetite clay-based for introducing a high-potential nano carrier for breast cancer was investigated. Synthesis of nano-carriers was based on three types of modified clay nano colloids) CbNC), magnetite (MNC) and clay-based magnetite nano carriers (MCbNC). The physicochemical properties of the synthesized samples were investigated by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), thermal analysis (TGA) and energy X-ray analysis (EDX). Also, flow cytometry and MTT were used to investigate the induction of apoptosis and toxicity, respectively. In this study, the physicochemical properties of the compounds after surface modification were improved compared to other studies, and the MCbNC compound showed anticancer and apoptosis-inducing properties (96 %) at a lower concentration (IC50,500 μM) than the other two compounds.http://www.sciencedirect.com/science/article/pii/S2405844025009491Nano colloidsPhysicochemical propertiesInduction of apoptosis |
| spellingShingle | Masoud Pourrahim Leila Zolghadr Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties Heliyon Nano colloids Physicochemical properties Induction of apoptosis |
| title | Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties |
| title_full | Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties |
| title_fullStr | Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties |
| title_full_unstemmed | Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties |
| title_short | Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties |
| title_sort | clay based magnetite nano carriers for breast cancer treatment apoptosis induction and physicochemical properties |
| topic | Nano colloids Physicochemical properties Induction of apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025009491 |
| work_keys_str_mv | AT masoudpourrahim claybasedmagnetitenanocarriersforbreastcancertreatmentapoptosisinductionandphysicochemicalproperties AT leilazolghadr claybasedmagnetitenanocarriersforbreastcancertreatmentapoptosisinductionandphysicochemicalproperties |