Unphysiological lung strain promotes ventilation-induced lung injury via activation of the PECAM-1/Src/STAT3 signaling pathway

Unphysiological lung strain promotes ventilation-induced lung injury via activation of the PECAM-1/Src/STAT3 signaling pathway

IntroductionIn patients with acute respiratory distress syndrome, mechanical ventilation often leads to ventilation-induced lung injury (VILI), which is attributed to unphysiological lung strain (UPLS) in respiratory dynamics. Platelet endothelial cell adhesion molecule-1 (PECAM-1), a transmembrane...

Full description

Saved in:
Bibliographic Details
Main Authors: Gang Liu, Bin-Bin Dong, Zi-Heng Ding, Chao Lan, Chang-Ju Zhu, Qi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
ventilation-induced lung injury
unphysiological lung strain
PECAM-1
Src/STAT3
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1469783/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items