The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation
Abstract Objective The pan-immune inflammatory (PIV) index holds prognostic value for cardiovascular diseases. This study aimed to investigate the predictive value of the PIV index regarding recurrence of atrial fibrillation (AF) after cryoballoon ablation (CBA). Methods The study included 307 patie...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12872-024-04329-5 |
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| author | Pengyang Gu Peng Xu Yiqun Chen Jingyu Li Hanrui Sun Haixia Xu Qi Lu |
| author_facet | Pengyang Gu Peng Xu Yiqun Chen Jingyu Li Hanrui Sun Haixia Xu Qi Lu |
| author_sort | Pengyang Gu |
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| description | Abstract Objective The pan-immune inflammatory (PIV) index holds prognostic value for cardiovascular diseases. This study aimed to investigate the predictive value of the PIV index regarding recurrence of atrial fibrillation (AF) after cryoballoon ablation (CBA). Methods The study included 307 patients with AF. Four inflammatory markers, namely, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation (SII) index, and PIV index, were used as indicators. COX regression analysis was conducted to evaluate the predictive value of AF recurrence after CBA. A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated to evaluate the discriminative power of the indicators. Result The PIV index [94.9 (168.9,504.9) vs. 143.2 (98.2,210.6), P < 0.01] and SII index [366.3 (256.6,491.9) vs. 569.9 (658.1,438.4), P < 0.01] were significantly higher in the recurrence group. Univariable COX regression analysis showed that these four indices, persistent AF, and left atrial diameter (LAD) were all associated with AF recurrence. In multivariable regression analysis, the PIV index, persistent AF, and LAD (all P < 0.05) were independent predictors of postoperative AF recurrence. The ROC curve analysis showed that the PIV index had a higher predictive value for AF recurrence (AUC = 0.768, P < 0.01, 95% CI: 0.696–0.840) than the SII index and NLR. Kaplan–Meier analysis showed that patients with a PIV index > 260.7 had a higher recurrence rate at 1-year follow-up (P < 0.01). Subgroup analysis indicated that PIV had a predictive value in patients with different types of AF. Conclusion PIV index may be a potential biomarker for predicting relapse in patients with AF after CBA. |
| format | Article |
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| institution | OA Journals |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-e502aed146c34d40a7b5a27612ba31ac2025-08-20T02:22:25ZengBMCBMC Cardiovascular Disorders1471-22612024-11-012411810.1186/s12872-024-04329-5The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablationPengyang Gu0Peng Xu1Yiqun Chen2Jingyu Li3Hanrui Sun4Haixia Xu5Qi Lu6Department of Cardiology, Cardiac Arrhythmia Center, Affiliated Hospital of Nantong UniversityThe Sixth People’s Hospital of NantongMedical College of Nantong UniversityDepartment of Cardiology, Cardiac Arrhythmia Center, Affiliated Hospital of Nantong UniversityDepartment of Cardiology, Cardiac Arrhythmia Center, Affiliated Hospital of Nantong UniversityDepartment of Cardiology, Cardiac Arrhythmia Center, Affiliated Hospital of Nantong UniversityDepartment of Cardiology, Cardiac Arrhythmia Center, Affiliated Hospital of Nantong UniversityAbstract Objective The pan-immune inflammatory (PIV) index holds prognostic value for cardiovascular diseases. This study aimed to investigate the predictive value of the PIV index regarding recurrence of atrial fibrillation (AF) after cryoballoon ablation (CBA). Methods The study included 307 patients with AF. Four inflammatory markers, namely, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation (SII) index, and PIV index, were used as indicators. COX regression analysis was conducted to evaluate the predictive value of AF recurrence after CBA. A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated to evaluate the discriminative power of the indicators. Result The PIV index [94.9 (168.9,504.9) vs. 143.2 (98.2,210.6), P < 0.01] and SII index [366.3 (256.6,491.9) vs. 569.9 (658.1,438.4), P < 0.01] were significantly higher in the recurrence group. Univariable COX regression analysis showed that these four indices, persistent AF, and left atrial diameter (LAD) were all associated with AF recurrence. In multivariable regression analysis, the PIV index, persistent AF, and LAD (all P < 0.05) were independent predictors of postoperative AF recurrence. The ROC curve analysis showed that the PIV index had a higher predictive value for AF recurrence (AUC = 0.768, P < 0.01, 95% CI: 0.696–0.840) than the SII index and NLR. Kaplan–Meier analysis showed that patients with a PIV index > 260.7 had a higher recurrence rate at 1-year follow-up (P < 0.01). Subgroup analysis indicated that PIV had a predictive value in patients with different types of AF. Conclusion PIV index may be a potential biomarker for predicting relapse in patients with AF after CBA.https://doi.org/10.1186/s12872-024-04329-5Pan-immune inflammatory indexSystemic immune indexAtrial fibrillationCryoballoon ablation |
| spellingShingle | Pengyang Gu Peng Xu Yiqun Chen Jingyu Li Hanrui Sun Haixia Xu Qi Lu The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation BMC Cardiovascular Disorders Pan-immune inflammatory index Systemic immune index Atrial fibrillation Cryoballoon ablation |
| title | The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation |
| title_full | The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation |
| title_fullStr | The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation |
| title_full_unstemmed | The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation |
| title_short | The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation |
| title_sort | predictive value of pan immune inflammatory index for early recurrence of atrial fibrillation after cryoablation |
| topic | Pan-immune inflammatory index Systemic immune index Atrial fibrillation Cryoballoon ablation |
| url | https://doi.org/10.1186/s12872-024-04329-5 |
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