Role of Complement in Multiorgan Failure
Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/962927 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553365296381952 |
|---|---|
| author | Daniel Rittirsch Heinz Redl Markus Huber-Lang |
| author_facet | Daniel Rittirsch Heinz Redl Markus Huber-Lang |
| author_sort | Daniel Rittirsch |
| collection | DOAJ |
| description | Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. In the present review, mechanisms of the inflammatory response in the development of MOF in sepsis and SIRS with particular focus on the complement system are discussed. |
| format | Article |
| id | doaj-art-e50259350bec4a0fb9877c3f747860a0 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e50259350bec4a0fb9877c3f747860a02025-02-03T05:54:16ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/962927962927Role of Complement in Multiorgan FailureDaniel Rittirsch0Heinz Redl1Markus Huber-Lang2Division of Trauma Surgery, Department of Surgery, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandLudwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center for Traumatology, 1200 Vienna, AustriaDepartment of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Hospital Ulm, 89075 Ulm, GermanyMultiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. In the present review, mechanisms of the inflammatory response in the development of MOF in sepsis and SIRS with particular focus on the complement system are discussed.http://dx.doi.org/10.1155/2012/962927 |
| spellingShingle | Daniel Rittirsch Heinz Redl Markus Huber-Lang Role of Complement in Multiorgan Failure Clinical and Developmental Immunology |
| title | Role of Complement in Multiorgan Failure |
| title_full | Role of Complement in Multiorgan Failure |
| title_fullStr | Role of Complement in Multiorgan Failure |
| title_full_unstemmed | Role of Complement in Multiorgan Failure |
| title_short | Role of Complement in Multiorgan Failure |
| title_sort | role of complement in multiorgan failure |
| url | http://dx.doi.org/10.1155/2012/962927 |
| work_keys_str_mv | AT danielrittirsch roleofcomplementinmultiorganfailure AT heinzredl roleofcomplementinmultiorganfailure AT markushuberlang roleofcomplementinmultiorganfailure |