DRP1, fission and apoptosis
Abstract Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metaboli...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-04-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02458-0 |
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| _version_ | 1850184362587324416 |
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| author | Nan Wang Xinwai Wang Beiwu Lan Yufei Gao Yuanyuan Cai |
| author_facet | Nan Wang Xinwai Wang Beiwu Lan Yufei Gao Yuanyuan Cai |
| author_sort | Nan Wang |
| collection | DOAJ |
| description | Abstract Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves multiple cellular events and interactions between organelles. As a pivotal molecule in the process of mitochondrial fission, the function of DRP1 is regulated at multiple levels, including transcription, post-translational modifications. This review follows the guidelines for Human Gene Nomenclature and will focus on DRP1, discussing its activity regulation, its role in mitochondrial fission, and the relationship between mitochondrial fission and apoptosis. |
| format | Article |
| id | doaj-art-e501931884e4444ba4f1bfff1a2a6f99 |
| institution | OA Journals |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-e501931884e4444ba4f1bfff1a2a6f992025-08-20T02:17:04ZengNature Publishing GroupCell Death Discovery2058-77162025-04-011111910.1038/s41420-025-02458-0DRP1, fission and apoptosisNan Wang0Xinwai Wang1Beiwu Lan2Yufei Gao3Yuanyuan Cai4The Department of Neurosurgery, China-Japan Union Hospital of Jilin UniversityThe Department of Neurosurgery, China-Japan Union Hospital of Jilin UniversityThe Department of Neurosurgery, China-Japan Union Hospital of Jilin UniversityThe Department of Neurosurgery, China-Japan Union Hospital of Jilin UniversityThe First Department of Neurology, China-Japan Union Hospital of Jilin UniversityAbstract Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves multiple cellular events and interactions between organelles. As a pivotal molecule in the process of mitochondrial fission, the function of DRP1 is regulated at multiple levels, including transcription, post-translational modifications. This review follows the guidelines for Human Gene Nomenclature and will focus on DRP1, discussing its activity regulation, its role in mitochondrial fission, and the relationship between mitochondrial fission and apoptosis.https://doi.org/10.1038/s41420-025-02458-0 |
| spellingShingle | Nan Wang Xinwai Wang Beiwu Lan Yufei Gao Yuanyuan Cai DRP1, fission and apoptosis Cell Death Discovery |
| title | DRP1, fission and apoptosis |
| title_full | DRP1, fission and apoptosis |
| title_fullStr | DRP1, fission and apoptosis |
| title_full_unstemmed | DRP1, fission and apoptosis |
| title_short | DRP1, fission and apoptosis |
| title_sort | drp1 fission and apoptosis |
| url | https://doi.org/10.1038/s41420-025-02458-0 |
| work_keys_str_mv | AT nanwang drp1fissionandapoptosis AT xinwaiwang drp1fissionandapoptosis AT beiwulan drp1fissionandapoptosis AT yufeigao drp1fissionandapoptosis AT yuanyuancai drp1fissionandapoptosis |