Uncovering the effects of ATBC plasticizers on intracerebral hemorrhage outcomes based on network toxicology and in vitro and in vivo experimental validation

Uncovering the effects of ATBC plasticizers on intracerebral hemorrhage outcomes based on network toxicology and in vitro and in vivo experimental validation

In recent years, the incidence of intracerebral hemorrhage (ICH) has been increasing steadily. Environmental factors, such as plastic usage and chemical exposure, have been implicated in exacerbating cerebrovascular disease outcomes, including ICH. Acetyl tributyl citrate (ATBC), a non-phthalate pla...

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Bibliographic Details
Main Authors: Jia-Wei Wu, Yi-Ting Zhou, Bing-Xin Wang, Peng Wang, Xu-Qi Zhang, Xiao-Jie Lu, Zeng-Li Miao, Xu-Dong Zhao
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
ATBC
ICH
Network toxicology
Molecular docking
SRC-STAT3 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325008267
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