Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen
Internal migrants are a challenge for TB control in large Chinese cities and understanding this epidemiology is crucial for designing effective control and prevention strategies. We conducted a prospective genomic epidemiological study of culture-positive TB patients diagnosed between June 1, 2018 a...
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2287119 |
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| author | Peierdun Mijiti Changwei Liu Chuangyue Hong Meng Li Xiaoping Tan Kaiqiao Zheng Bin Li Lecai Ji Qizhi Mao Qi Jiang Howard Takiff Hongxia Fang Weiguo Tan Qian Gao |
| author_facet | Peierdun Mijiti Changwei Liu Chuangyue Hong Meng Li Xiaoping Tan Kaiqiao Zheng Bin Li Lecai Ji Qizhi Mao Qi Jiang Howard Takiff Hongxia Fang Weiguo Tan Qian Gao |
| author_sort | Peierdun Mijiti |
| collection | DOAJ |
| description | Internal migrants are a challenge for TB control in large Chinese cities and understanding this epidemiology is crucial for designing effective control and prevention strategies. We conducted a prospective genomic epidemiological study of culture-positive TB patients diagnosed between June 1, 2018 and May 31, 2021 in the Longhua District of Shenzhen. Treatment status was obtained from local and national TB registries and all isolates were sequenced. Genomic clusters were defined as strains differing by ≤12 SNPs. Risk factors for clustering were identified with multivariable analysis and then Bayesian models and TransPhylo were used to infer the timing of transmission within clusters. Of the 2277 culture-positive patients, 70.1% (1596/2277) were migrants: 72.1% (1043/1446) of the migrants patients developed TB within two years of arriving in Longhua; 38.8% within 6 months of arriving; and 12.3% (104/843) had TB symptoms when they arrived. Only 15.4% of Longhua strains were in genomic clusters. More than one third (33.6%) of patients were not treated in Shenzhen but were involved in nearly one third of the recent transmission events. Clustering was associated with migrants not treated in Shenzhen, males, and teachers/trainers. TB in Longhua is prinicipally due to reactivation of infections in migrants, but a proportion may have had clinical or incipient TB upon arrival in the district. Patients diagnosed but not treated in Longhua were involved in recent local TB transmission. Controlling TB in Shenzhen will require strategies to comprehensively diagnose and treat active TB in the internal migrant population. |
| format | Article |
| id | doaj-art-e4fee54383794978aed28d904b2bb649 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-e4fee54383794978aed28d904b2bb6492025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2023.2287119Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in ShenzhenPeierdun Mijiti0Changwei Liu1Chuangyue Hong2Meng Li3Xiaoping Tan4Kaiqiao Zheng5Bin Li6Lecai Ji7Qizhi Mao8Qi Jiang9Howard Takiff10Hongxia Fang11Weiguo Tan12Qian Gao13Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of ChinaLonghua District Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaShenzhen Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of ChinaLonghua District Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaLonghua District Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaLonghua District Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaShenzhen Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of ChinaLaboratorio de Genética Molecular, CMBC, IVIC, Caracas, VenezuelaLonghua District Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaShenzhen Center for Chronic Disease Control, Shenzhen, People’s Republic of ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of ChinaInternal migrants are a challenge for TB control in large Chinese cities and understanding this epidemiology is crucial for designing effective control and prevention strategies. We conducted a prospective genomic epidemiological study of culture-positive TB patients diagnosed between June 1, 2018 and May 31, 2021 in the Longhua District of Shenzhen. Treatment status was obtained from local and national TB registries and all isolates were sequenced. Genomic clusters were defined as strains differing by ≤12 SNPs. Risk factors for clustering were identified with multivariable analysis and then Bayesian models and TransPhylo were used to infer the timing of transmission within clusters. Of the 2277 culture-positive patients, 70.1% (1596/2277) were migrants: 72.1% (1043/1446) of the migrants patients developed TB within two years of arriving in Longhua; 38.8% within 6 months of arriving; and 12.3% (104/843) had TB symptoms when they arrived. Only 15.4% of Longhua strains were in genomic clusters. More than one third (33.6%) of patients were not treated in Shenzhen but were involved in nearly one third of the recent transmission events. Clustering was associated with migrants not treated in Shenzhen, males, and teachers/trainers. TB in Longhua is prinicipally due to reactivation of infections in migrants, but a proportion may have had clinical or incipient TB upon arrival in the district. Patients diagnosed but not treated in Longhua were involved in recent local TB transmission. Controlling TB in Shenzhen will require strategies to comprehensively diagnose and treat active TB in the internal migrant population.https://www.tandfonline.com/doi/10.1080/22221751.2023.2287119Tuberculosistransmissioninternal migrantswhole-genome sequencing |
| spellingShingle | Peierdun Mijiti Changwei Liu Chuangyue Hong Meng Li Xiaoping Tan Kaiqiao Zheng Bin Li Lecai Ji Qizhi Mao Qi Jiang Howard Takiff Hongxia Fang Weiguo Tan Qian Gao Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen Emerging Microbes and Infections Tuberculosis transmission internal migrants whole-genome sequencing |
| title | Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen |
| title_full | Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen |
| title_fullStr | Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen |
| title_full_unstemmed | Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen |
| title_short | Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen |
| title_sort | implications for tb control among migrants in large cities in china a prospective population based genomic epidemiology study in shenzhen |
| topic | Tuberculosis transmission internal migrants whole-genome sequencing |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2287119 |
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