Assessment of minimum clinically important difference in symptoms and functionality of Japanese patients with major depressive disorder following inadequate response to antidepressants: a post hoc analysis of the long-term study of brexpiprazole augmentation therapy in Japanese patients with major depressive disorder

Assessment of minimum clinically important difference in symptoms and functionality of Japanese patients with major depressive disorder following inadequate response to antidepressants: a post hoc analysis of the long-term study of brexpiprazole augmentation therapy in Japanese patients with major depressive disorder

Background and objectivesThe aim of this study was to apply the minimum clinically important difference (MCID) concept to clinical results for Japanese patients with major depressive disorder following inadequate response to antidepressants, and to explore the disparity in what physicians and patien...

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Bibliographic Details
Main Authors: Hikaru Hori, Masako Shiosakai, Yoshiyuki Shibasaki, Kentaro Yamato, Yilong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Psychiatry
Subjects:
major depressive disorder
minimum clinically important difference
Montgomery-Åsberg depression rating scale
Sheehan disability scale
EuroQol 5-dimension 5-level
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1556470/full
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