Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.

<h4>Background</h4>Use of narcotic or "recreational" drugs has been associated with adverse pregnancy outcomes such as preterm delivery. However, the associations might be confounded by other factors related to high-risk behaviours. This is the first study to investigate the as...

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Main Authors: Siavash Maghsoudlou, Sven Cnattingius, Scott Montgomery, Mohsen Aarabi, Shahriar Semnani, Anna-Karin Wikström, Shahram Bahmanyar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0176588&type=printable
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author Siavash Maghsoudlou
Sven Cnattingius
Scott Montgomery
Mohsen Aarabi
Shahriar Semnani
Anna-Karin Wikström
Shahram Bahmanyar
author_facet Siavash Maghsoudlou
Sven Cnattingius
Scott Montgomery
Mohsen Aarabi
Shahriar Semnani
Anna-Karin Wikström
Shahram Bahmanyar
author_sort Siavash Maghsoudlou
collection DOAJ
description <h4>Background</h4>Use of narcotic or "recreational" drugs has been associated with adverse pregnancy outcomes such as preterm delivery. However, the associations might be confounded by other factors related to high-risk behaviours. This is the first study to investigate the association between traditional opium use during pregnancy and risk of preterm delivery.<h4>Method and findings</h4>We performed a population-based cohort study in the rural areas of the Golestan province, Iran between 2008 and 2010. We randomly selected 920 women who used (usually smoked) opium during pregnancy and 920 women who did not. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations between the opium use during pregnancy and preterm delivery and adjustment was made for potential confounding factors. This study shows compared with non-use of opium and tobacco, use of only opium during pregnancy was associated with an increased risk of preterm delivery (OR = 1.56; 95% CI 1.05-2.32), and the risk was more than two-fold increased among dual users of opium and tobacco (OR = 2.31; 95% CI 1.37-3.90). We observed that opium use only was associated with a doubled risk for preterm caesarean delivery (OR = 2.05; 95% CI 1.10-3.82) but not for preterm vaginal delivery (OR = 1.25; 95% CI 0.75-2.07). Dual use of opium and tobacco was associated with a substantially increased risk of vaginal preterm delivery (OR = 2.58; 95% CI 1.41-4.71).<h4>Conclusions</h4>Opium use during pregnancy among non-tobacco smokers is associated with an increased risk of preterm caesarean delivery, indicating an increased risk of a compromised foetus before or during labour. Women who use both opium and smoked during pregnancy have an increased risk of preterm vaginal delivery, indicating an increased risk of spontaneous preterm delivery.
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spelling doaj-art-e4fd40f9b0c2450ab675c117d005b5592025-01-21T05:31:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017658810.1371/journal.pone.0176588Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.Siavash MaghsoudlouSven CnattingiusScott MontgomeryMohsen AarabiShahriar SemnaniAnna-Karin WikströmShahram Bahmanyar<h4>Background</h4>Use of narcotic or "recreational" drugs has been associated with adverse pregnancy outcomes such as preterm delivery. However, the associations might be confounded by other factors related to high-risk behaviours. This is the first study to investigate the association between traditional opium use during pregnancy and risk of preterm delivery.<h4>Method and findings</h4>We performed a population-based cohort study in the rural areas of the Golestan province, Iran between 2008 and 2010. We randomly selected 920 women who used (usually smoked) opium during pregnancy and 920 women who did not. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations between the opium use during pregnancy and preterm delivery and adjustment was made for potential confounding factors. This study shows compared with non-use of opium and tobacco, use of only opium during pregnancy was associated with an increased risk of preterm delivery (OR = 1.56; 95% CI 1.05-2.32), and the risk was more than two-fold increased among dual users of opium and tobacco (OR = 2.31; 95% CI 1.37-3.90). We observed that opium use only was associated with a doubled risk for preterm caesarean delivery (OR = 2.05; 95% CI 1.10-3.82) but not for preterm vaginal delivery (OR = 1.25; 95% CI 0.75-2.07). Dual use of opium and tobacco was associated with a substantially increased risk of vaginal preterm delivery (OR = 2.58; 95% CI 1.41-4.71).<h4>Conclusions</h4>Opium use during pregnancy among non-tobacco smokers is associated with an increased risk of preterm caesarean delivery, indicating an increased risk of a compromised foetus before or during labour. Women who use both opium and smoked during pregnancy have an increased risk of preterm vaginal delivery, indicating an increased risk of spontaneous preterm delivery.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0176588&type=printable
spellingShingle Siavash Maghsoudlou
Sven Cnattingius
Scott Montgomery
Mohsen Aarabi
Shahriar Semnani
Anna-Karin Wikström
Shahram Bahmanyar
Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
PLoS ONE
title Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
title_full Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
title_fullStr Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
title_full_unstemmed Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
title_short Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
title_sort opium use during pregnancy and risk of preterm delivery a population based cohort study
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0176588&type=printable
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AT scottmontgomery opiumuseduringpregnancyandriskofpretermdeliveryapopulationbasedcohortstudy
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